Document Detail

Fetal platelet consumption: a feature of placental insufficiency.
MedLine Citation:
PMID:  2002988     Owner:  NLM     Status:  MEDLINE    
The involvement of fetal platelets in placental insufficiency was investigated. Platelet life span and the rate of platelet turnover were measured by a novel technique in fetuses with moderate and severe placental insufficiency and in controls. This procedure involves the measurement of platelet count and concentration of free glycocalicin in plasma. Placental insufficiency was defined by antenatal Doppler ultrasound analysis of the umbilical artery waveform, which was used to categorize the subjects according to whether their systolic-diastolic ratios were normal, moderately raised, or severely raised. Mean platelet life span in fetuses affected by placental insufficiency was only 60% of the normal fetal platelet life span (P less than .001). In addition, affected fetuses had a higher rate of platelet turnover, reflected in an elevated plasma glycocalicin concentration (4.06 +/- 0.19 versus 3.28 +/- 0.15 microgram/mL for severe placental insufficiency and control fetuses, respectively; P less than .01). Platelet life span did not differ between the moderate and severe placental insufficiency groups. We hypothesize that the observed changes in platelet life span and turnover result from increased platelet activation, which plays a role in the development of placental insufficiency.
G R Wilcox; B J Trudinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  77     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-04-18     Completed Date:  1991-04-18     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  616-21     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Sydney, Westmead Hospital, New South Wales, Australia.
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MeSH Terms
Fetal Blood*
Placental Insufficiency / blood*
Platelet Aggregation Inhibitors / metabolism*
Platelet Count
Platelet Glycoprotein GPIb-IX Complex*
Platelet Membrane Glycoproteins / metabolism*
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIb-IX Complex; 0/Platelet Membrane Glycoproteins; 0/glycocalicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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