Document Detail

Fetal pathology in second-trimester miscarriages.
MedLine Citation:
PMID:  19349700     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We aimed to analyze, based upon autopsy, the main characteristics of miscarriages in the second trimester. METHODS: We have processed the results of fetopathological investigations of 544 aborted fetuses resulting from 486 second-trimester miscarriages. RESULTS: Malformation could be identified in 13.05% of all cases. In almost one third of the patients there was a positive history. In the cases having a malformation, expressed dominance of male fetuses could be observed. Among the fetopathologically identified malformations, 49 were isolated. The most common was the single umbilical artery (22.4%). In 1.3% of the cases a chromosome aberration was verified. CONCLUSION: Miscarriage in pregnancies complicated by a malformation occurs approximately 3 weeks earlier than in cases without a confirmed malformation. There is practically no difference between affected and unaffected miscarriages as far as the cumulative ratio of positive history is concerned. A single umbilical artery alone predisposes to miscarriage, while in association with other malformations it may result from chromosome aberration.
József Gábor Joó; Artúr Beke; Eniko Berkes; Zoltán Papp; János Rigó; Csaba Papp
Publication Detail:
Type:  Journal Article     Date:  2009-04-07
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  25     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-26     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  186-91     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 S. Karger AG, Basel.
First Department of Obstetrics and Gynaecology, Faculty of General Medicine, Semmelweis University, Budapest, Hungary.
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MeSH Terms
Abortion, Habitual / epidemiology
Abortion, Spontaneous / epidemiology*,  genetics,  pathology
Chromosome Aberrations
Congenital Abnormalities / epidemiology,  genetics,  pathology
Fetal Development
Pregnancy Trimester, Second*
Sex Ratio

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