Document Detail

Fetal outcome in trial of antihypertensive treatment in pregnancy.
MedLine Citation:
PMID:  61439     Owner:  NLM     Status:  MEDLINE    
242 women completed a controlled trial of methyldopa ('Aldomet') for moderate hypertension in pregnancy. Active treatment was associated with a significantly improved fetal outcome, due in part to a reduced number of mid-pregnancy abortions. There were 9 pregnancy losses in the control group, which included 4 mid-pregnancy abortions, and 1 fetal loss in the treated group. The birthweight and maturity of viable infants were similar in treated and control groups, and a detailed multivariate analysis confirmed that hypotensive treatment had no effect on fetal growth in utero. The better outcome associated with treatment was not due to the prevention of pre-eclampsia, and may be partly due to a direct or indirect effect of methyldopa on uterine activity. Methyldopa is safe to use for the treatment of hypertension in pregnancy in the context of close medical and obstetric supervision.
C W Redman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-01     Completed Date:  1976-12-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  753-6     Citation Subset:  AIM; IM    
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MeSH Terms
Abortion, Spontaneous / epidemiology
Birth Weight*
Clinical Trials as Topic
Drug Evaluation
Fetal Death / epidemiology
Fetus / drug effects*,  physiology
Follow-Up Studies
Hypertension / drug therapy*
Infant, Newborn
Infant, Newborn, Diseases / etiology,  mortality
Methyldopa / therapeutic use*
Pre-Eclampsia / complications,  drug therapy,  epidemiology
Pregnancy Complications, Cardiovascular / drug therapy*
Pregnancy Trimester, Second
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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