| Fetal outcome in trial of antihypertensive treatment in pregnancy. | |
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MedLine Citation:
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PMID: 61439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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242 women completed a controlled trial of methyldopa ('Aldomet') for moderate hypertension in pregnancy. Active treatment was associated with a significantly improved fetal outcome, due in part to a reduced number of mid-pregnancy abortions. There were 9 pregnancy losses in the control group, which included 4 mid-pregnancy abortions, and 1 fetal loss in the treated group. The birthweight and maturity of viable infants were similar in treated and control groups, and a detailed multivariate analysis confirmed that hypotensive treatment had no effect on fetal growth in utero. The better outcome associated with treatment was not due to the prevention of pre-eclampsia, and may be partly due to a direct or indirect effect of methyldopa on uterine activity. Methyldopa is safe to use for the treatment of hypertension in pregnancy in the context of close medical and obstetric supervision. |
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Authors:
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C W Redman |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Lancet Volume: 2 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1976 Oct |
Date Detail:
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Created Date: 1976-12-01 Completed Date: 1976-12-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 753-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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epidemiology Adult Birth Weight* Clinical Trials as Topic Drug Evaluation Female Fetal Death / epidemiology Fetus / drug effects*, physiology Follow-Up Studies Growth Humans Hypertension / drug therapy* Infant, Newborn Infant, Newborn, Diseases / etiology, mortality Methyldopa / therapeutic use* Pre-Eclampsia / complications, drug therapy, epidemiology Pregnancy Pregnancy Complications, Cardiovascular / drug therapy* Pregnancy Trimester, Second |
| Chemical | |
Reg. No./Substance:
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555-30-6/Methyldopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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