Document Detail


Fetal outcome in trial of antihypertensive treatment in pregnancy.
MedLine Citation:
PMID:  61439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
242 women completed a controlled trial of methyldopa ('Aldomet') for moderate hypertension in pregnancy. Active treatment was associated with a significantly improved fetal outcome, due in part to a reduced number of mid-pregnancy abortions. There were 9 pregnancy losses in the control group, which included 4 mid-pregnancy abortions, and 1 fetal loss in the treated group. The birthweight and maturity of viable infants were similar in treated and control groups, and a detailed multivariate analysis confirmed that hypotensive treatment had no effect on fetal growth in utero. The better outcome associated with treatment was not due to the prevention of pre-eclampsia, and may be partly due to a direct or indirect effect of methyldopa on uterine activity. Methyldopa is safe to use for the treatment of hypertension in pregnancy in the context of close medical and obstetric supervision.
Authors:
C W Redman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-01     Completed Date:  1976-12-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  753-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / epidemiology
Adult
Birth Weight*
Clinical Trials as Topic
Drug Evaluation
Female
Fetal Death / epidemiology
Fetus / drug effects*,  physiology
Follow-Up Studies
Growth
Humans
Hypertension / drug therapy*
Infant, Newborn
Infant, Newborn, Diseases / etiology,  mortality
Methyldopa / therapeutic use*
Pre-Eclampsia / complications,  drug therapy,  epidemiology
Pregnancy
Pregnancy Complications, Cardiovascular / drug therapy*
Pregnancy Trimester, Second
Chemical
Reg. No./Substance:
555-30-6/Methyldopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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