Document Detail

Fetal nutrition and muscle oxygen supply in childhood.
MedLine Citation:
PMID:  12489069     Owner:  NLM     Status:  MEDLINE    
Fetal undernutrition may increase the risk of insulin resistance syndrome in adult life and low birth weight carries with it the risk of endothelial dysfunction. We studied 59 prepubertal and adolescent children whose birth weight exceeded 2.5 kg. We related their birth weight and ponderal index (PI) (weight/length(3)) at birth to muscle oxygen supply (assessed by near infrared spectroscopy [NIRS]) and to variables associated with increased risk of developing the insulin resistance syndrome (ie, abdominal subcutaneous and visceral fat volumes, percentage body fat, fasting leptin, insulin, and glucose levels). Birth weight was not associated with muscle oxygen supply or any other independent variable measured. In the prepubertal group, there was a significant inverse relation between PI and muscle reoxygenation half-time in both the male (R =.58, P =.03) and female (R =.72, P =.009) groups. This relationship was not present in either the male (R =.03, P =.90) or female (R =.09, P =.75) adolescent groups. In a population in which low birth weight subjects were excluded, low PI at birth is associated with poor muscle oxygen supply in early childhood, but this relationship is not present in adolescence.
Fiona Arrowsmith; Julie Ward; Andrew Ling; Kieron Rooney; Louise Baur; Campbell Thompson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  51     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-18     Completed Date:  2003-01-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1569-72     Citation Subset:  IM    
Copyright Information:
Copyright 2002, Elsevier Science (USA). All rights reserved.
Department of Paediatrics, University of Sydney, NSW, Australia.
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MeSH Terms
Biological Availability
Birth Weight
Body Height
Fetus / physiology*
Muscle, Skeletal / metabolism*
Nutritional Physiological Phenomena / physiology*
Oxygen / metabolism
Oxygen Consumption*
Spectroscopy, Near-Infrared
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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