Document Detail

Fetal and neonatal outcomes in twin oligohydramnios-polyhydramnios sequence including cerebral palsy.
MedLine Citation:
PMID:  12169809     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to review consecutive pregnancies complicated by twin oligohydramnios-polyhydramnios sequence (TOPS) and to clarify the probable factors influencing the perinatal outcomes. METHODS: Twenty-five pregnancies with a diagnosis of TOPS were treated with and without amniocentesis. A poor perinatal outcome was defined when either perinatal mortality or cerebral palsy was observed. RESULTS: The mean gestational age at the time of diagnosis and of delivery was 27.8 (range 21-34) and 30.7 (range 23-35) weeks, respectively. Tocolytic therapy and therapeutic amniocentesis were done in 16 (64%) and 13 (52%) cases. Hydrops fetalis was present in 10 cases. The survival rate was 72%, and cerebral palsy was diagnosed in 8 of 36 infants (22%). The poor prognostic factors were gestational age at delivery (<30 weeks) and presence of symptomatic preterm labor and hydrops fetalis. Therapeutic amniocentesis did not influence the perinatal outcome. CONCLUSIONS: In this observational study, the long-term as well as the short-term perinatal outcome of pregnancy with TOPS seems to be poor. In addition, therapeutic amniocentesis in TOPS does not appear to affect fetal and neonatal outcomes.
Yoshio Matsuda; Satoshi Kouno
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Publication Detail:
Type:  Journal Article; Twin Study    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  17     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2002-08-09     Completed Date:  2003-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  268-71     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima, Japan.
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MeSH Terms
Cerebral Palsy / mortality*
Cohort Studies
Fetofetal Transfusion / diagnosis,  mortality*,  therapy
Hydrops Fetalis / diagnosis,  mortality,  therapy
Infant, Newborn
Oligohydramnios / diagnosis,  mortality*,  therapy
Polyhydramnios / diagnosis,  mortality*,  therapy
Pregnancy Outcome
Retrospective Studies

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