Document Detail

Fetal and neonatal habituation in infants of diabetic mothers.
MedLine Citation:
PMID:  19054526     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate whether maternal diabetes alters the habituation ability of fetuses and newborns. STUDY DESIGN: Two nonrandomized clinical trials were performed. First, we studied prenatal fetuses of women with pregestational diabetes, and control subjects matched for gestational age, and then we studied infants of diabetic mothers (IDM) and control subjects matched for gestational age and mode of delivery. Fetus and newborns were stimulated with vibroacoustic stimulus. RESULTS: In fetuses of diabetic mothers, the ability to habituate was lower, and the habituation rate was higher than in control subjects to all habituation tests. In the neonatal period, ability to habituate was lower (59% vs 100%; P< .001), and the habituation rate was higher (18 [14-21] vs 4 [1.2-6.8]; P< .001) in the IDM than in the control infants. We found a significant negative correlation between maternal glycosylated hemoglobin in each trimester of pregnancy and habituation ability in IDM. CONCLUSIONS: Fetuses and infants of diabetic mothers have impaired habituation ability, which is related to the degree of maternal metabolic control.
N L Gonzalez-Gonzalez; V Medina; E Padron; E Domenech; N M Diaz Gomez; H Armas; J L Bartha
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-12-03
Journal Detail:
Title:  The Journal of pediatrics     Volume:  154     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-27     Completed Date:  2009-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  492-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University Hospital of the Canary Islands, Tenerife, Canary Islands, Spain.
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MeSH Terms
Acoustic Stimulation
Central Nervous System / embryology,  growth & development*
Child of Impaired Parents*
Fetus / physiology*
Habituation, Psychophysiologic*
Infant, Newborn / physiology*
Pregnancy Trimesters
Pregnancy in Diabetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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