Document Detail

Fetal and neonatal exposure to nicotine disrupts ovarian function and fertility in adult female rats.
MedLine Citation:
PMID:  17322582     Owner:  NLM     Status:  MEDLINE    
Women born to mothers who smoked during pregnancy have been shown to have impaired fertility, although the mechanisms underlying this association are unknown. Nicotine administration in adult animals has adverse effects on the ovary and uterus; however, the effects of fetal exposure to nicotine on postnatal ovarian function have not been determined. The goal of this study was to assess the effect of fetal and neonatal exposure to nicotine on ovarian function and fertility of the offspring. Nulliparous female Wistar rats were given 1 nicotine bitartrate, subcutaneously for 14 d prior to mating, during pregnancy and throughout lactation until weaning. Measures of fertility, breeding success, and serum levels of ovarian steroid hormones in offspring were assessed at 4 and 6 mo of age. Fetal and neonatal exposure to nicotine significantly increased the time to pregnancy as the animals aged. Similarly, evidence of altered ovarian steroidogenesis including increased serum progesterone concentrations and a decreased estrogen:progesterone ratio was observed in 6-mo-old animals. We conclude that fetal and neonatal exposure to nicotine results in delayed ovarian dysfunction in adult female offspring.
A C Holloway; L D Kellenberger; J J Petrik
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine     Volume:  30     ISSN:  1355-008X     ISO Abbreviation:  Endocrine     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2007-02-26     Completed Date:  2007-04-23     Revised Date:  2010-06-24    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-6     Citation Subset:  IM    
Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada.
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MeSH Terms
Animals, Newborn* / blood
Cotinine / blood
Fertility / drug effects*
Gonadal Steroid Hormones / analysis
Nicotine / adverse effects*
Ovary / chemistry,  drug effects*,  physiology
Pregnancy, Animal / drug effects
Prenatal Exposure Delayed Effects* / blood
Rats, Wistar
Reg. No./Substance:
0/Gonadal Steroid Hormones; 486-56-6/Cotinine; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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