Document Detail


Fetal and neonatal bone health: update on bone growth and manifestations in health and disease.
MedLine Citation:
PMID:  22395728     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The neonatal period is classically described as the first 28 days of life, but owing to the fact that changes in skeletal tissue occur at a somewhat slower pace than those of other organ systems, events of the first few months are considered herein. Neonatal bone health is a problem of growing interest and concern because of the increasing recognition of its impact upon childhood, adolescent and even adult bone health. Osteoporosis in adulthood often has its roots in childhood and some forms may be prevented by proper attention to neonatal and childhood bone health. The premature infant likely suffers lifelong decreased bone mineral density as a result of its early birth and lack of adequate mineral stores that are typically present in full-term infants. Adequate embryogenesis, growth and development of the skeletal system are multifactorial and under the influence of a host of genes, growth factors and enzymes. The evaluation of skeletal dysplasias and their recognition are beyond the scope of this paper and will not be considered in this discussion. Here the focus will be on the adequacy of mineralization and metabolic aspects of the growth and development of the fetal and neonatal skeleton, the effect of birth, both preterm and term, maternal illness and health as well as infant diseases.
Authors:
Stephen L Done
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Publication Detail:
Type:  Journal Article     Date:  2012-03-06
Journal Detail:
Title:  Pediatric radiology     Volume:  42 Suppl 1     ISSN:  1432-1998     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  158-76     Citation Subset:  IM    
Affiliation:
Department of Radiology, Seattle Children's Hospital, University of Washington, R5417, 4800 Sandpoint Way NE, Seattle, WA, 98105, USA, stephen.done@seattlechildrens.org.
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