Document Detail

Fetal nasal bone length in euploid and aneuploid fetuses between 11 and 20 weeks' gestation: a prospective study.
MedLine Citation:
PMID:  15448323     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To develop normative data for nasal bone length between 11 and 20 weeks' gestation and to assess the utility of nasal bone hypoplasia in the detection of fetal aneuploidy in the second trimester. METHODS: Well-dated, nonanomalous fetuses were examined between 11 and 20.9 weeks' gestation. The nasal bone was assessed and measured, and normative data from 11 to 20 weeks' gestation were determined. The nasal bone lengths in fetuses with confirmed aneuploidy were compared with the normative data. RESULTS: The fetal nasal bone length increased linearly with advancing gestational age. Nomograms including the 10th, 50th, and 90th percentiles were created. Nasal bone hypoplasia was seen in 6 of 6 cases of fetal trisomy in the second trimester. CONCLUSIONS: Nasal bone hypoplasia in the early second trimester identifies a cohort of fetuses at high risk for aneuploidy.
William Cusick; Jacquelyn Provenzano; Christopher A Sullivan; Francene M Gallousis; John F Rodis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  23     ISSN:  0278-4297     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-27     Completed Date:  2005-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1327-33     Citation Subset:  IM    
Division of Maternal-Fetal Medicine, The Stamford Hospital, Shelburne at West Broad Street, Stamford, CT 06904, USA.
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MeSH Terms
Cross-Sectional Studies
Fetus / anatomy & histology*
Gestational Age
Nasal Bone / embryology*,  ultrasonography*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prospective Studies
Reference Values
Ultrasonography, Prenatal*

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