Document Detail

Fetal mortality in oral cleft families (VII): Birth intervals.
MedLine Citation:
PMID:  6713707     Owner:  NLM     Status:  MEDLINE    
Birth intervals in sibships of oral cleft probands are analysed to detect prolonged delays between successive pregnancies. Such intervals are useful indicators of undetected fetal mortality. The present study indicates that the average interval for 462 cleft families in Indiana is 30.61 months. The average interval leading to the birth of a cleft child is 33.94 and is significantly greater than the average interval for the entire sample. Although the contraception status of the Indiana population is not known, the significantly greater delay preceding the birth of a cleft child is indicative of a cause other than contraception. This finding is in agreement with the report by Drillien et al. (1966) that abnormal conceptions occur more frequently adjacent to cleft offspring. It is interesting that some increase in the average interval is also noted in the present study immediately following the birth of a cleft child. Such delays occurring both preceding and following the birth of a cleft child (in contrast to smaller intervals for other pregnancies in the same sibships) may indicate excessive fetal wastage due to a combination of genetic and environmental factors.
K R Dronamraju; D Bixler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical genetics     Volume:  25     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-06-08     Completed Date:  1984-06-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  318-22     Citation Subset:  IM    
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MeSH Terms
Birth Intervals*
Cleft Lip / genetics*
Cleft Palate / genetics*
Epidemiologic Methods
Fetal Death / epidemiology,  genetics*
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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