Document Detail


Fetal microchimerism in skin wound healing.
MedLine Citation:
PMID:  22627845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Skin wound healing is a complex regenerative process involving various cell types. We recently investigated whether fetal microchimeric cells (FMCs) acquired during gestation contribute to maternal wound healing and used fetal microchimerism to investigate the recruitment of distant endothelial progenitor cells in skin wounds. Our study showed that fetal progenitor cells are recruited into maternal wounds and participate in inflammation and angiogenesis. These fetal cells might have beneficial effects in situations of maternal defective healing, and might also modify the adult maternal wound environment toward a scarless fetal-like wound healing.
Authors:
Dany Nassar; Kiarash Khosrotehrani; Selim Aractingi
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Publication Detail:
Type:  Journal Article     Date:  2012-04-01
Journal Detail:
Title:  Chimerism     Volume:  3     ISSN:  1938-1964     ISO Abbreviation:  Chimerism     Publication Date:    2012 Apr-Jun
Date Detail:
Created Date:  2012-08-29     Completed Date:  2013-01-24     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  101540510     Medline TA:  Chimerism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  45-7     Citation Subset:  IM    
Affiliation:
Université Pierre et Marie Curie; Paris, France. dany.nassar@inserm.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Chimerism*
Collagenases / genetics,  metabolism
Endothelial Cells / cytology
Female
Fetus / cytology
Inflammation / immunology,  metabolism
Mice
Neovascularization, Physiologic
Pregnancy
Skin / blood supply,  injuries,  metabolism
Stem Cell Transplantation
Stem Cells / cytology
Transforming Growth Factor beta1 / genetics,  metabolism
Wound Healing*
Chemical
Reg. No./Substance:
0/Transforming Growth Factor beta1; EC 3.4.24.-/Collagenases; EC 3.4.24.-/collagenase 1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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