| Fetal and maternal response to intravenous infusion of a thromboxane synthetase inhibitor. | |
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MedLine Citation:
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PMID: 2220946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pharmacologic inhibition of thromboxane synthetase activity has reversed the clinical manifestations of toxemia in the ovine model. To investigate placental transfer and fetal effects of a selective thromboxane synthetase inhibitor, CGS13080 (Ciba-Geigy, Summit, N.J.) was intravenously infused into eight singleton- or twin-bearing ewes near term. During CGS 13080 infusion (0.1 mg/kg/hr), maternal steady-state CGS 13080 levels of 102 +/- 18 ng/ml were achieved within 30 minutes and maternal serum thromboxane generation decreased significantly (13 +/- 3 to 4 +/- 1 ng/ml). However, fetal serum levels of CGS 13080 were only 4% of peak maternal concentrations and fetal serum thromboxane generation did not change. There was no evidence of change in uterine blood flow, maternal or fetal blood pressure, heart rate, blood gas values, or fetal or maternal metabolites of prostacyclin or prostaglandin E2 during the study. We speculate that CGS 13080 may be efficacious in the treatment of human pregnancy-induced hypertension. |
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Authors:
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J P Cardin; M G Ross; M G Ervin; A V Schaffer; F L Douglas; J P Simke |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 163 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1990-11-16 Completed Date: 1990-11-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1345-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Harbor-University of California at Los Angeles, Torrance 90509. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Fetus / drug effects* Hypertension / drug therapy* Imidazoles / administration & dosage, blood, pharmacology* Immunosuppressive Agents / pharmacology* Pregnancy Pregnancy Complications, Cardiovascular / drug therapy* Prostaglandins / blood* Pyridines / administration & dosage, blood, pharmacology* Sheep Thromboxane-A Synthase / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Imidazoles; 0/Immunosuppressive Agents; 0/Prostaglandins; 0/Pyridines; 85691-74-3/pirmagrel; EC 5.3.99.5/Thromboxane-A Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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