Document Detail


Fetal and maternal hemodynamics in acute malaria during pregnancy.
MedLine Citation:
PMID:  22795756     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To measure maternal and fetal hemodynamics during acute malaria in pregnancy. METHODS: Time courses of maternal heart rate (MHR), maternal blood pressure (BP), and fetal heart rate (FHR) were performed until 56days after initiation of anti-malarial treatment with artemether-lumefantrine. Women with malaria were hospitalized for at least 3days until recovery. RESULTS: Mean baseline characteristics of pregnant women with malaria (n=38) versus pregnant women without malaria (n=39) were as follows: gestational age (28.8 vs 24.6weeks; P=0.006); maximum FHR (165.3 vs 158.3 beats per minute [bpm]; P=0.054); minimum FHR (137.6 vs 128.7bpm; P=0.016); mean BP (74.7 vs 80.9mm Hg; P=0.001); pulse pressure (40.3 vs 42.1mm Hg; P=0.300); and MHR (107.4 vs 81.3bpm; P<0.001). The geometric mean parasite count was 13 795 per μL. Complete time courses were collected from a subgroup of participants. For women with malaria, maternal body temperature and BP normalized within 24hours and after 72hours, respectively. The MHR among pregnant women without malaria showed a physiologic increase during pregnancy of approximately 7bpm between days 0 and 56. The mean FHR among women with malaria normalized after 72hours. CONCLUSION: Acute malaria induces maternal and fetal hemodynamic changes.
Authors:
Stephen Rulisa; Nadine Kaligirwa; Steven Agaba; Placide Karangayire; Petra F Mens; Peter J de Vries
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-12
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  -     ISSN:  1879-3479     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Affiliation:
National University of Rwanda, University Teaching Hospital of Kigali, Kigali, Rwanda; Center for Poverty Related Communicable Diseases (CPCD), Academic Medical Center, Amsterdam, The Netherlands.
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