Document Detail

Fetal and maternal factors associated with infant mortality in vervet monkeys.
MedLine Citation:
PMID:  20637047     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Causes of infant death remain unknown in significant proportions of human and non-human primate pregnancies.
METHODS: A closed breeding colony with high rates of infant mortality had pregnancies assessed (n=153) by fetal measurements and maternal characteristics. Infant outcome was classified as neonatal death (stillborn or died <48 hours from birth), postnatal death (died 2-30 days) or surviving (alive after 30 days).
RESULTS: Fetal size did not predict outcome. Poor maternal glycemic control and low social ranking increased odds for adverse outcome (OR=3.72, P=0.01 and 2.27, P=0.04, respectively). Male sex was over-represented in stillbirths (P=0.04), and many were macrosomic, but size did not associate with maternal glycemic control measured as glycated hemoglobin A1c. Postnatally dead infants were smaller (P<0.01), which associated with behavioral factors and glycemic control.
CONCLUSIONS: Fetal growth estimates predicted gestational age but not fetal outcome. Maternal social status and metabolic health, particularly glycemic control, increased risks of adverse pregnancy outcome.
K Kavanagh; B L Dozier; T J Chavanne; L A Fairbanks; M J Jorgensen; J R Kaplan
Related Documents :
14552367 - Stillbirth in the pig in relation to genetic merit for farrowing survival.
18720637 - Maternal mortality in bahrain 1987-2004: an audit of causes of avoidable death.
11710687 - Myometrial fibers in the placental basal plate can confirm but do not necessarily indic...
19439457 - Micronutrient supplementation affects maternal-infant feeding interactions and maternal...
17202867 - Maternal smoking and environmental tobacco smoke exposure and the risk of orofacial cle...
871217 - Pharmacokinetic observations of phenytoin disposition in the newborn and young infant.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of medical primatology     Volume:  40     ISSN:  1600-0684     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-05     Completed Date:  2011-04-11     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  27-36     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Animals, Newborn
Cercopithecus aethiops*
Diabetes, Gestational / veterinary
Fetal Development
Fetal Macrosomia / mortality,  veterinary
Gestational Age
Hemoglobin A, Glycosylated / analysis
Hierarchy, Social
Hyperglycemia / complications,  veterinary
Monkey Diseases / etiology*
Pregnancy Complications / veterinary*
Pregnancy Outcome
Sex Factors
Stillbirth / epidemiology,  veterinary*
Ultrasonography, Prenatal / veterinary
Grant Support
K01 AG033641/AG/NIA NIH HHS; K01 AG033641/AG/NIA NIH HHS; K01 AG033641-01A1/AG/NIA NIH HHS; P40 RR 019963/RR/NCRR NIH HHS; T35 RR 025836/RR/NCRR NIH HHS
Reg. No./Substance:
0/Hemoglobin A, Glycosylated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Case of splenogonadal fusion in an adult.
Next Document:  Cattle ancestry in bison: explanations for higher mtDNA than autosomal ancestry.