| Fetal and maternal factors associated with infant mortality in vervet monkeys. | |
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MedLine Citation:
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PMID: 20637047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Causes of infant death remain unknown in significant proportions of human and non-human primate pregnancies. METHODS: A closed breeding colony with high rates of infant mortality had pregnancies assessed (n=153) by fetal measurements and maternal characteristics. Infant outcome was classified as neonatal death (stillborn or died <48 hours from birth), postnatal death (died 2-30 days) or surviving (alive after 30 days). RESULTS: Fetal size did not predict outcome. Poor maternal glycemic control and low social ranking increased odds for adverse outcome (OR=3.72, P=0.01 and 2.27, P=0.04, respectively). Male sex was over-represented in stillbirths (P=0.04), and many were macrosomic, but size did not associate with maternal glycemic control measured as glycated hemoglobin A1c. Postnatally dead infants were smaller (P<0.01), which associated with behavioral factors and glycemic control. CONCLUSIONS: Fetal growth estimates predicted gestational age but not fetal outcome. Maternal social status and metabolic health, particularly glycemic control, increased risks of adverse pregnancy outcome. |
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Authors:
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K Kavanagh; B L Dozier; T J Chavanne; L A Fairbanks; M J Jorgensen; J R Kaplan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of medical primatology Volume: 40 ISSN: 1600-0684 ISO Abbreviation: J. Med. Primatol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-05 Completed Date: 2011-04-11 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 0320626 Medline TA: J Med Primatol Country: Denmark |
Other Details:
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Languages: eng Pagination: 27-36 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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Pathology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC, USA. kkavanag@wfubmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Cercopithecus aethiops* Diabetes, Gestational / veterinary Female Fetal Development Fetal Macrosomia / mortality, veterinary Gestational Age Hemoglobin A, Glycosylated / analysis Hierarchy, Social Hyperglycemia / complications, veterinary Male Monkey Diseases / etiology* Pregnancy Pregnancy Complications / veterinary* Pregnancy Outcome Sex Factors Stillbirth / epidemiology, veterinary* Ultrasonography, Prenatal / veterinary |
| Grant Support | |
ID/Acronym/Agency:
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K01 AG033641/AG/NIA NIH HHS; K01 AG033641-01A1/AG/NIA NIH HHS; P40 RR 019963/RR/NCRR NIH HHS; T35 RR 025836/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin A, Glycosylated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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