Document Detail


Fetal and maternal factors associated with infant mortality in vervet monkeys.
MedLine Citation:
PMID:  20637047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Causes of infant death remain unknown in significant proportions of human and non-human primate pregnancies.
METHODS: A closed breeding colony with high rates of infant mortality had pregnancies assessed (n=153) by fetal measurements and maternal characteristics. Infant outcome was classified as neonatal death (stillborn or died <48 hours from birth), postnatal death (died 2-30 days) or surviving (alive after 30 days).
RESULTS: Fetal size did not predict outcome. Poor maternal glycemic control and low social ranking increased odds for adverse outcome (OR=3.72, P=0.01 and 2.27, P=0.04, respectively). Male sex was over-represented in stillbirths (P=0.04), and many were macrosomic, but size did not associate with maternal glycemic control measured as glycated hemoglobin A1c. Postnatally dead infants were smaller (P<0.01), which associated with behavioral factors and glycemic control.
CONCLUSIONS: Fetal growth estimates predicted gestational age but not fetal outcome. Maternal social status and metabolic health, particularly glycemic control, increased risks of adverse pregnancy outcome.
Authors:
K Kavanagh; B L Dozier; T J Chavanne; L A Fairbanks; M J Jorgensen; J R Kaplan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of medical primatology     Volume:  40     ISSN:  1600-0684     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-05     Completed Date:  2011-04-11     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  27-36     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Cercopithecus aethiops*
Diabetes, Gestational / veterinary
Female
Fetal Development
Fetal Macrosomia / mortality,  veterinary
Gestational Age
Hemoglobin A, Glycosylated / analysis
Hierarchy, Social
Hyperglycemia / complications,  veterinary
Male
Monkey Diseases / etiology*
Pregnancy
Pregnancy Complications / veterinary*
Pregnancy Outcome
Sex Factors
Stillbirth / epidemiology,  veterinary*
Ultrasonography, Prenatal / veterinary
Grant Support
ID/Acronym/Agency:
K01 AG033641/AG/NIA NIH HHS; K01 AG033641/AG/NIA NIH HHS; K01 AG033641-01A1/AG/NIA NIH HHS; P40 RR 019963/RR/NCRR NIH HHS; T35 RR 025836/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobin A, Glycosylated
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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