Document Detail


Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells.
MedLine Citation:
PMID:  19631389     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Human leukocyte antigen-C (HLA-C) is the only polymorphic classical histocompatibility antigen expressed by fetal trophoblasts at the fetal-maternal interface. Interactions between HLA-C and decidual natural killer (NK) cells may facilitate trophoblast invasion into maternal tissue. Thus far no evidence has been provided that decidual T cells specifically recognize and respond to fetal alloantigens at the fetal-maternal interface. In this study, we show that pregnancies containing a HLA-C mismatched child induce an increased percentage of CD4(+)CD25(dim) activated T cells in decidual tissue. In addition, HLA-C mismatched pregnancies exhibit a decidual lymphocyte response to fetal cells and contain functional CD4(+)CD25(bright) regulatory T cells in decidual tissue, whereas HLA-C matched pregnancies do not. This suggests that decidual T cells specifically recognize fetal HLA-C at the fetal-maternal interface but are prevented from inducing a destructive immune response in uncomplicated pregnancies.
Authors:
Tamara Tilburgs; Sicco A Scherjon; Barbara J van der Mast; Geert W Haasnoot; Minke Versteeg-V D Voort-Maarschalk; Dave L Roelen; Johannes J van Rood; Frans H J Claas
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Publication Detail:
Type:  Journal Article     Date:  2009-07-23
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  82     ISSN:  1872-7603     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  148-57     Citation Subset:  IM    
Affiliation:
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands. T.Tilburgs@LUMC.nl
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