| Fetal malformations associated with the use of methylphenobarbital and carbamazepine during pregnancy. Two case reports and review of the literature. | |
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MedLine Citation:
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PMID: 19218807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of antiepileptic drugs (AEDs) during pregnancy has been associated with an increased risk of major and minor fetal malformations. This paper describes 2 infants with malformations born to epileptic mothers who used AEDs throughout pregnancy. In the first case, the AED used for seizure control was methylphenobarbital, while in the second case the patient had been prescribed carbamazepine. We noted major and minor congenital malformations in both infants exposed in utero to these anticonvulsant drugs. Pregnant women still experience poor obstetrical care because they report to tertiary centers at the end of their pregnancy or when in labor, making it difficult to provide proper medical care for both the infant and the mother. |
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Authors:
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Alenka Aksamija; Dubravko Habek; Milan Stanojević; Boris Ujević |
Related Documents
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9068887 - Contraception, pregnancy and lactation in women with epilepsy. 15936867 - Drug intake behaviour of immigrants during pregnancy. 18032047 - The internal control group in a register of antiepileptic drug use in pregnancy. 16990737 - Treatment with oxcarbazepine during pregnancy. 8513617 - The relationship between heart rate and asphyxia in the animal fetus. 12266217 - Al-azar experience in pregnancy associated hypertension. |
Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2009-02-13 |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 25 ISSN: 1421-9964 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-08-26 Completed Date: 2009-11-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 79-82 Citation Subset: IM |
Copyright Information:
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(c) 2009 S. Karger AG, Basel. |
Affiliation:
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Clinic of Gynecology and Obstetrics, Sveti Duh General Hospital, Zagreb, Croatia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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epidemiology,
etiology* Adult Anticonvulsants / adverse effects*, therapeutic use Carbamazepine / adverse effects*, therapeutic use Epilepsy / drug therapy Female Humans Male Maternal Exposure* Mephobarbital / adverse effects*, therapeutic use Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 115-38-8/Mephobarbital; 298-46-4/Carbamazepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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