Document Detail

Fetal malformations associated with the use of methylphenobarbital and carbamazepine during pregnancy. Two case reports and review of the literature.
MedLine Citation:
PMID:  19218807     Owner:  NLM     Status:  MEDLINE    
The use of antiepileptic drugs (AEDs) during pregnancy has been associated with an increased risk of major and minor fetal malformations. This paper describes 2 infants with malformations born to epileptic mothers who used AEDs throughout pregnancy. In the first case, the AED used for seizure control was methylphenobarbital, while in the second case the patient had been prescribed carbamazepine. We noted major and minor congenital malformations in both infants exposed in utero to these anticonvulsant drugs. Pregnant women still experience poor obstetrical care because they report to tertiary centers at the end of their pregnancy or when in labor, making it difficult to provide proper medical care for both the infant and the mother.
Alenka Aksamija; Dubravko Habek; Milan Stanojević; Boris Ujević
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-02-13
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  25     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-26     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  79-82     Citation Subset:  IM    
Copyright Information:
(c) 2009 S. Karger AG, Basel.
Clinic of Gynecology and Obstetrics, Sveti Duh General Hospital, Zagreb, Croatia.
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MeSH Terms
Abnormalities, Drug-Induced / epidemiology,  etiology*
Anticonvulsants / adverse effects*,  therapeutic use
Carbamazepine / adverse effects*,  therapeutic use
Epilepsy / drug therapy
Maternal Exposure*
Mephobarbital / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Anticonvulsants; 115-38-8/Mephobarbital; 298-46-4/Carbamazepine

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