Document Detail


Fetal male gender and the benefits of treatment of mild gestational diabetes mellitus.
MedLine Citation:
PMID:  22542118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We evaluated whether improvements in pregnancy outcomes after treatment of mild gestational diabetes mellitus differed in magnitude on the basis of fetal gender.
STUDY DESIGN: This is a secondary analysis of a masked randomized controlled trial of treatment for mild gestational diabetes mellitus. The results included preeclampsia or gestational hypertension, birthweight, neonatal fat mass, and composite adverse outcomes for both neonate (preterm birth, small for gestational age, or neonatal intensive care unit admission) and mother (labor induction, cesarean delivery, preeclampsia, or gestational hypertension). After stratification according to fetal gender, the interaction of gender with treatment status was estimated for these outcomes.
RESULTS: Of the 469 pregnancies with male fetuses, 244 pregnancies were assigned randomly to treatment, and 225 pregnancies were assigned randomly to routine care. Of the 463 pregnancies with female fetuses, 233 pregnancies were assigned randomly to treatment, and 230 pregnancies were assigned randomly to routine care. The interaction of gender with treatment status was significant for fat mass (P = .04) and birthweight percentile (P = .02). Among women who were assigned to the treatment group, male offspring were significantly more likely to have both a lower birthweight percentile (50.7 ± 29.2 vs 62.5 ± 30.2 percentile; P < .0001) and less neonatal fat mass (487 ± 229.6 g vs 416.6 ± 172.8 g; P = .0005,) whereas these differences were not significant among female offspring. There was no interaction between fetal gender and treatment group with regard to other outcomes.
CONCLUSION: The magnitude of the reduction of a newborn's birthweight percentile and neonatal fat mass that were related to the treatment of mild gestational diabetes mellitus appears greater for male neonates.
Authors:
Ray O Bahado-Singh; Lisa Mele; Mark B Landon; Susan M Ramin; Marshall W Carpenter; Brian Casey; Ronald J Wapner; Michael W Varner; Dwight J Rouse; John M Thorp; Anthony Sciscione; Patrick Catalano; Margaret Harper; George Saade; Steve N Caritis; Alan M Peaceman; Jorge E Tolosa;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-03-23
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  206     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-30     Completed Date:  2012-07-27     Revised Date:  2014-08-27    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422.e1-5     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012. Published by Mosby, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adiposity*
Birth Weight*
Diabetes, Gestational / therapy*
Diet Therapy*
Female
Humans
Hypoglycemic Agents / therapeutic use*
Infant, Newborn
Insulin / therapeutic use*
Male
Pregnancy
Pregnancy Outcome
Sex Factors
Treatment Outcome
Grant Support
ID/Acronym/Agency:
C06-RR11234/RR/NCRR NIH HHS; HD21410/HD/NICHD NIH HHS; HD27860/HD/NICHD NIH HHS; HD27915/HD/NICHD NIH HHS; HD27917/HD/NICHD NIH HHS; HD34116/HD/NICHD NIH HHS; HD34136/HD/NICHD NIH HHS; HD34208, HD27869/HD/NICHD NIH HHS; HD36801/HD/NICHD NIH HHS; HD40485/HD/NICHD NIH HHS; HD40500/HD/NICHD NIH HHS; HD40512/HD/NICHD NIH HHS; HD40544/HD/NICHD NIH HHS; HD40545/HD/NICHD NIH HHS; HD40560/HD/NICHD NIH HHS; HD53097/HD/NICHD NIH HHS; HD53118/HD/NICHD NIH HHS; M01-RR00034/RR/NCRR NIH HHS; M01-RR00080/RR/NCRR NIH HHS; U10 HD027917/HD/NICHD NIH HHS; UL1 RR024989/RR/NCRR NIH HHS; UL1-RR024989/RR/NCRR NIH HHS; UL1-RR025764/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents; 0/Insulin
Investigator
Investigator/Affiliation:
Y Sorokin / ; G Norman / ; P Lockhart / ; S Blackwell / ; L Quast / ; K Leveno / ; L Moseley / ; J Gold / ; D Bradford / ; L Fay / ; M Garcia / ; F Capellan / ; M Miodovnik / ; F Malone / ; S Bousleiman / ; H Husami / ; V Carmona / ; N Fredericks / ; E Gantioqui / ; B Greenspan / ; M Williams / ; K Anderson / ; P Ashby / ; S McAllister / ; S Quinn / ; F Castinella / ; A Guzman / ; J Steiner / ; J Parker / ; J Sheppard / ; J Tisdale / ; A Northen / ; W Andrews / ; D Catlow / ; D Allard / ; M Seebeck / ; J Tillinghast / ; J Iams / ; F Johnson / ; C Latimer / ; E Weinandy / ; B Maselli / ; K Dorman / ; S Brody / ; S Timlin / ; J Bernhardt / ; M Hoffman / ; E Guzman / ; M Talucci / ; T Grossman / ; C Perez / ; L Zeghibe / ; P Tabangin / ; B Mercer / ; B Stetzer / ; C Milluzzi / ; W Dalton / ; S Pichette / ; M Swain / ; P Meis / ; J White / ; L Gilstrap / ; K Cannon / ; J Martinez / ; D Dusek / ; J Moss / ; J Brandon / ; A Jackson / ; G Hankins / ; D Sharp / ; M Bickus / ; H Birkland / ; M Cotroneo / ; N Cuddy / ; P Simon / ; G Mallett / ; L Davis / ; E Lairson / ; C Cromett / ; C Naze / ; M Blaser / ; E Thom / ; J Zachary / ; B Getachew / ; C Cobb / ; L Leuchtenburg / ; S Gilbert / ; C Spong / ; S Tolivaisa / ; K Howell / ; G D Anderson /
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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