Document Detail

Fetal lung maturation in congenital diaphragmatic hernia.
MedLine Citation:
PMID:  7503176     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to determine whether congenital diaphragmatic hernia is associated with abnormalities of fetal lung maturation. STUDY DESIGN: We measured surfactant protein A and saturated phosphatidylcholine in amniotic fluid from 19 pregnancies with a prenatal diagnosis of congenital diaphragmatic hernia (gestational age 16 to 40 weeks) and 48 control pregnancies (gestational age 16 to 39 weeks). Results were compared by analysis of covariance. RESULTS: Beyond 34 weeks of gestation there was a progressive rise in amniotic fluid surfactant protein A and saturated phosphatidylcholine in control pregnancies, whereas in most fetuses with prenatal diagnosis of congenital diaphragmatic hernia these values remained low (p < 0.01). Amniotic fluid surfactant protein A was lower in fetuses with congenital diaphragmatic hernia who died or required extracorporeal membrane oxygenation than in survivors treated with conventional management (4.9 +/- 2.9 vs 16.8 +/- 5.7 micrograms/ml surfactant protein A, respectively, p < 0.05 by Mann-Whitney U test). CONCLUSIONS: There are decreased surfactant components in amniotic fluid in many pregnancies complicated by congenital diaphragmatic hernia, which may reflect fetal lung immaturity or hypoplasia.
F R Moya; V L Thomas; J Romaguera; M R Mysore; M Maberry; A Bernard; M Freund
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  173     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-01-16     Completed Date:  1996-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1401-5     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063, USA.
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MeSH Terms
Biological Markers / analysis
Extracorporeal Membrane Oxygenation
Fetal Death
Gestational Age
Glycoproteins / analysis
Hernia, Diaphragmatic / congenital*,  diagnosis*,  physiopathology
Lung / embryology*
Phosphatidylcholines / analysis*
Proteolipids / analysis*
Pulmonary Surfactant-Associated Proteins
Pulmonary Surfactants / analysis*
Reference Values
Reg. No./Substance:
0/Biological Markers; 0/Glycoproteins; 0/Phosphatidylcholines; 0/Proteolipids; 0/Pulmonary Surfactant-Associated Proteins; 0/Pulmonary Surfactants

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