Document Detail


Fetal lung maturation: amniotic fluid catecholamines, phospholipids, and cortisol.
MedLine Citation:
PMID:  7058846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The identification of beta-adrenergic receptors in the fetal lung led us to investigate amniotic fluid catecholamine levels in relation to other indices of fetal pulmonary maturity in late pregnancies (n = 62). Significant correlations were found between the percentage of phosphatidylglycerol and concentrations of norepinephrine (r = 0.44, p less than 0.001), its intraneuronal deaminated metabolite 3,4-dihydroxyphenylglycerol (DOPEG; r = 0.74, p less than 0.0001), epinephrine (4 = 0.43, p less than 0.001), and cortisol (r = 0.78, p less than 0.001). Highly significant elevations of these substances were noted with accelerated pulmonary maturation. Lecithin/sphingomyelin (L/S) ratios showed a significant correlation with cortisol levels (r = 0.50, p less than 0.001); however, significant associations between L/S ratios and catecholamine levels were found only when complicated pregnancies were excluded. These findings support the contention that fetal contention that fetal adrenergic activity participates in the process of pulmonary maturation.
Authors:
W A Divers; A Babaknia; B R Hopper; M M Wilkes; S S Yen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  142     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  440-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid / analysis*
Catecholamines / analysis*
Epinephrine / analysis
Female
Fetal Organ Maturity
Humans
Hydrocortisone / analysis*
Lung / embryology*
Methoxyhydroxyphenylglycol / analogs & derivatives,  analysis
Norepinephrine / analysis
Phosphatidylcholines / analysis
Phosphatidylglycerols / analysis*
Pregnancy
Sphingomyelins / analysis
Grant Support
ID/Acronym/Agency:
HD-12303/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Phosphatidylcholines; 0/Phosphatidylglycerols; 0/Sphingomyelins; 3343-19-9/dihydroxyphenylethylene glycol; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 534-82-7/Methoxyhydroxyphenylglycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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