| Fetal lung maturation: amniotic fluid catecholamines, phospholipids, and cortisol. | |
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MedLine Citation:
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PMID: 7058846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The identification of beta-adrenergic receptors in the fetal lung led us to investigate amniotic fluid catecholamine levels in relation to other indices of fetal pulmonary maturity in late pregnancies (n = 62). Significant correlations were found between the percentage of phosphatidylglycerol and concentrations of norepinephrine (r = 0.44, p less than 0.001), its intraneuronal deaminated metabolite 3,4-dihydroxyphenylglycerol (DOPEG; r = 0.74, p less than 0.0001), epinephrine (4 = 0.43, p less than 0.001), and cortisol (r = 0.78, p less than 0.001). Highly significant elevations of these substances were noted with accelerated pulmonary maturation. Lecithin/sphingomyelin (L/S) ratios showed a significant correlation with cortisol levels (r = 0.50, p less than 0.001); however, significant associations between L/S ratios and catecholamine levels were found only when complicated pregnancies were excluded. These findings support the contention that fetal contention that fetal adrenergic activity participates in the process of pulmonary maturation. |
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Authors:
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W A Divers; A Babaknia; B R Hopper; M M Wilkes; S S Yen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 142 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1982 Feb |
Date Detail:
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Created Date: 1982-04-20 Completed Date: 1982-04-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 440-4 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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analysis* Catecholamines / analysis* Epinephrine / analysis Female Fetal Organ Maturity Humans Hydrocortisone / analysis* Lung / embryology* Methoxyhydroxyphenylglycol / analogs & derivatives, analysis Norepinephrine / analysis Phosphatidylcholines / analysis Phosphatidylglycerols / analysis* Pregnancy Sphingomyelins / analysis |
| Grant Support | |
ID/Acronym/Agency:
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HD-12303/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Phosphatidylcholines; 0/Phosphatidylglycerols; 0/Sphingomyelins; 3343-19-9/dihydroxyphenylethylene glycol; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 534-82-7/Methoxyhydroxyphenylglycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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