Document Detail

Fetal lung maturation: amniotic fluid catecholamines, phospholipids, and cortisol.
MedLine Citation:
PMID:  7058846     Owner:  NLM     Status:  MEDLINE    
The identification of beta-adrenergic receptors in the fetal lung led us to investigate amniotic fluid catecholamine levels in relation to other indices of fetal pulmonary maturity in late pregnancies (n = 62). Significant correlations were found between the percentage of phosphatidylglycerol and concentrations of norepinephrine (r = 0.44, p less than 0.001), its intraneuronal deaminated metabolite 3,4-dihydroxyphenylglycerol (DOPEG; r = 0.74, p less than 0.0001), epinephrine (4 = 0.43, p less than 0.001), and cortisol (r = 0.78, p less than 0.001). Highly significant elevations of these substances were noted with accelerated pulmonary maturation. Lecithin/sphingomyelin (L/S) ratios showed a significant correlation with cortisol levels (r = 0.50, p less than 0.001); however, significant associations between L/S ratios and catecholamine levels were found only when complicated pregnancies were excluded. These findings support the contention that fetal contention that fetal adrenergic activity participates in the process of pulmonary maturation.
W A Divers; A Babaknia; B R Hopper; M M Wilkes; S S Yen
Related Documents :
1799346 - Amniocentesis in the management of preterm premature rupture of the membranes.
42586 - Active management of high-risk pregnancy.
18249076 - Lung maturation in small for gestational age fetuses from pregnancies complicated by pl...
416716 - Response of immature baboon fetal lung to intra-amniotic betamethasone.
20080846 - Thyroid dysfunction and autoantibodies during pregnancy as predictive factors of pregna...
894266 - The mechanism of the inactivation of human fibroblast interferon by mechanical stress.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  142     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  440-4     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amniotic Fluid / analysis*
Catecholamines / analysis*
Epinephrine / analysis
Fetal Organ Maturity
Hydrocortisone / analysis*
Lung / embryology*
Methoxyhydroxyphenylglycol / analogs & derivatives,  analysis
Norepinephrine / analysis
Phosphatidylcholines / analysis
Phosphatidylglycerols / analysis*
Sphingomyelins / analysis
Grant Support
Reg. No./Substance:
0/Catecholamines; 0/Phosphatidylcholines; 0/Phosphatidylglycerols; 0/Sphingomyelins; 3343-19-9/dihydroxyphenylethylene glycol; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 534-82-7/Methoxyhydroxyphenylglycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sympathoadrenal activity in infants of diabetic mothers.
Next Document:  Fetal lung maturity: the adjunctive use of ultrasound.