| Fetal liver-sparing cardiovascular adaptations linked to mother's slimness and diet. | |
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MedLine Citation:
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PMID: 15576647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fetal adaptations to impaired maternoplacental nutrient supply include altered regional blood flow. Whether such responses operate within the normal range of maternal body composition or diet is unknown, but any change in fetal liver perfusion could alter hepatic development, with long-term consequences for the risk of cardiovascular and metabolic disease. In 381 low-risk pregnancies, we found that the fetuses of slimmer mothers with lower body fat stores and those eating an unbalanced diet had greater liver blood flow and shunted less blood away from the liver through the ductus venosus at 36 weeks gestation. Consequences of such "liver-sparing" may underlie the increased cardiovascular risk of people whose mothers were slimmer and had lower body fat stores in pregnancy. |
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Authors:
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Guttorm Haugen; Mark Hanson; Torvid Kiserud; Sarah Crozier; Hazel Inskip; Keith M Godfrey |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2004-12-02 |
Journal Detail:
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Title: Circulation research Volume: 96 ISSN: 1524-4571 ISO Abbreviation: Circ. Res. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-07 Completed Date: 2005-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: United States |
Other Details:
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Languages: eng Pagination: 12-4 Citation Subset: IM |
Affiliation:
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Division of Developmental Origins of Health and Disease, University of Southampton, Southampton, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Adipose Tissue / anatomy & histology* Adult Birth Weight Blood Flow Velocity Body Mass Index Cardiovascular Diseases / epidemiology Cardiovascular System / embryology Diabetes Mellitus, Type 2 / epidemiology Diet* Female Fetus / blood supply, physiology Gestational Age Humans Infant, Newborn Liver / blood supply*, embryology*, ultrasonography Malnutrition / physiopathology Maternal Age Organ Specificity Placenta / blood supply, ultrasonography Pregnancy / physiology* Pregnancy Complications / physiopathology Prenatal Exposure Delayed Effects* Questionnaires Risk Skinfold Thickness Thinness* / physiopathology Ultrasonography, Doppler Ultrasonography, Prenatal Umbilical Veins / ultrasonography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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