Document Detail

Fetal-like erythropoiesis during recovery from transient erythroblastopenia of childhood (TEC).
MedLine Citation:
PMID:  7254949     Owner:  NLM     Status:  MEDLINE    
Fetal-like erythropoiesis frequently accompanies marrow stress conditions such as Diamond-Blackfan syndrome and aplastic anemia. In contrast, patients with transient erythroblastopenia of childhood have erythrocytes which lack fetal characteristics at the time of diagnosis. This report describes nine children with transient erythroblastopenia of childhood in whom transient, fetal-like erythropoiesis was observed during the period of recovery. These patients initially presented with anemia, reticulocytopenia, erythrocytes of normal size for age, low levels of fetal hemoglobin, and i-antigen. During the recovery period, however, erythrocytes manifested one or more fetal characteristics. These included an increased fetal hemoglobin (in three of five patients), the presence of i-antigen (in four of six patients), and macrocytosis (in seven of nine patients). These fetal characteristics persisted more than 2 wk after the reticulocyte count returned to normal. Within one year from diagnosis, red blood cells contained no fetal characteristics.
M P Link; B P Alter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  15     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1036-9     Citation Subset:  IM    
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MeSH Terms
Anemia, Aplastic / blood*
Bone Marrow Diseases / blood
Child, Preschool
Fetal Blood / physiology*

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