Document Detail

Fetal leptin is a signal of fat mass independent of maternal nutrition in ewes fed at or above maintenance energy requirements.
MedLine Citation:
PMID:  12135887     Owner:  NLM     Status:  MEDLINE    
In adults, circulating leptin concentrations are dependent on body fat content and on current nutritional status. However, the relationships among maternal nutrient intake, fetal adiposity, and circulating leptin concentrations before birth are unknown. We investigated the effects of an increase in nutrient intake in the pregnant ewe on fetal adiposity and plasma leptin concentrations during late gestation. Between 115 and 139-141 days gestation (term = 147 +/- 3 days gestation), ewes were fed a diet calculated to provide either maintenance (control, n = 6) or approximately 155% of maintenance requirements (well-fed, n = 8). The fetal fat depots (perirenal and interscapular) were dissected, and the relative proportion of unilocular and multilocular adipocytes in each depot was determined. Maternal plasma glucose and leptin concentrations were significantly increased in well-fed ewes. Fetal plasma glucose concentrations were also higher in the well-fed group (115-139 days gestation: control, 1.65 +/- 0.14 mmol/L; well-fed, 2.00 +/- 0.14 mmol/L; F = 5.76, P < 0.04). There was no effect of increasing maternal feed intake on total fat mass, the relative mass of unilocular fat, or fetal plasma leptin concentrations (115-139 days gestation: control, 5.2 +/- 0.8 ng/ml; well-fed, 4.7 +/- 0.7 ng/ml). However, in both the control and well-fed groups fetal plasma leptin concentrations (y) were positively correlated with the relative mass of unilocular fat (x): y = 1.51x + 1.70; (R = 0.76, P < 0.01). Thus, fetal leptin may play a role as a signal of unilocular fat mass in the fetus when maternal nutrient intake is at or above maintenance requirements.
B S Mühlhäusler; C T Roberts; J R McFarlane; K G Kauter; I C McMillen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of reproduction     Volume:  67     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-23     Completed Date:  2003-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  493-9     Citation Subset:  IM    
Department of Physiology, Adelaide University, South Australia 5005, Australia.
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MeSH Terms
Adipose Tissue / anatomy & histology*,  metabolism*
Blood Gas Analysis
Blood Glucose / metabolism
Body Composition / physiology
Embryonic and Fetal Development / physiology
Energy Metabolism / physiology*
Fetus / metabolism*
Insulin / blood
Leptin / metabolism*
Nutritional Status*
Organ Size / physiology
Placenta / physiology
Reg. No./Substance:
0/Blood Glucose; 0/Leptin; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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