| Fetal learning about ethanol and later ethanol responsiveness: evidence against "safe" amounts of prenatal exposure. | |
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MedLine Citation:
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PMID: 18222969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Near-term fetuses of different mammalian species, including humans, exhibit functional sensory and learning capabilities. The neurobiological literature indicates that the unborn organism processes sensory stimuli present in the amniotic fluid, retains this information for considerable amounts of time, and is also capable of associating such stimuli with biologically relevant events. This research has stimulated studies aimed at the analysis of fetal and neonatal learning about ethanol, a topic that constitutes the core of the present review. Ethanol has characteristic sensory (olfactory, taste, and trigeminal) attributes and can exert pharmacologic reinforcing effects. The studies under examination support the hypothesis that low to moderate levels of maternal ethanol intoxication during late pregnancy set the opportunity for fetal learning about ethanol. These levels of prenatal ethanol exposure do not generate evident morphologic or neurobehavioral alterations in the offspring, but they exert a significant impact upon later ethanol-seeking and intake behaviors. Supported by preclinical and clinical findings, this review contributes to strengthening the case for the ability of prenatal ethanol exposure to have effects on the postnatal organism. |
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Authors:
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Paula Abate; Mariana Pueta; Norman E Spear; Juan C Molina |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Experimental biology and medicine (Maywood, N.J.) Volume: 233 ISSN: 1535-3702 ISO Abbreviation: Exp. Biol. Med. (Maywood) Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-28 Completed Date: 2008-03-14 Revised Date: 2011-02-08 |
Medline Journal Info:
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Nlm Unique ID: 100973463 Medline TA: Exp Biol Med (Maywood) Country: United States |
Other Details:
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Languages: eng Pagination: 139-54 Citation Subset: IM |
Affiliation:
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Instituto de Investigación Médica Mercedes y Martín Ferreyra C.P. 5016, Córdoba, Argentina. pabate@immf.uncor.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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drug effects Animals Drug Toxicity* Ethanol / adverse effects, pharmacology* Female Humans Learning / drug effects* Maternal Exposure* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 AA013098/AA/NIAAA NIH HHS; R01 AA015992/AA/NIAAA NIH HHS; R01 AA015992-02/AA/NIAAA NIH HHS; R01 AA1960-06/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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