Document Detail

Fetal lateral neck cysts: early second-trimester transvaginal diagnosis, natural history and clinical significance.
MedLine Citation:
PMID:  8903914     Owner:  NLM     Status:  MEDLINE    
The objective of the study was to explore the natural history and clinical significance of lateral neck cysts during the early second trimester of pregnancy. A survey was conducted of pregnant women at 12-15 weeks' gestation who presented at the ultrasonographic unit between January 1991 and December 1994. During the 4-year period, of the 1500 fetuses scanned, 42 fetuses with lateral neck cysts were detected by high-resolution transvaginal ultrasonography. Twenty-six of the 42 fetuses were seen to have isolated lateral neck cysts, and 16 demonstrated a combination of nuchal thickness of > or = 4 mm and lateral neck cysts. Natural history, fetal karyotype and pregnancy outcome were compared between these two groups. None of the fetuses with isolated neck cysts had an abnormal karyotype, and all cysts resolved spontaneously at 16-20 weeks. No congenital abnormalities were found among the 26 cases. Four chromosomal abnormalities (three trisomy 21 and one monosomy XO) were detected among the 16 fetuses with combined lesions, resulting in termination of pregnancy in all. Among the remaining 12 fetuses, spontaneous resolution of the neck findings occurred between 16 and 20 weeks' gestation. The finding of isolated lateral neck cysts in the early second trimester is not associated with increased risk of aneuploidy. However, the combination with nuchal thickness of > or = 4 mm should prompt genetic counselling and consideration of karyotyping, since this delay in maturation of the cervical jugular lymphatic communication may be associated with chromosomal aberrations.
R Achiron; S Yagel; A Weissman; S Lipitz; S Mashiach; B Goldman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  6     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-02-20     Completed Date:  1997-02-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  396-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Israel.
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MeSH Terms
Cohort Studies
Cysts / ultrasonography
Data Collection
Diagnosis, Differential
Down Syndrome / diagnosis*,  epidemiology,  ultrasonography
Fetal Diseases / diagnosis*,  epidemiology
Neck / pathology,  ultrasonography
Pregnancy Outcome*
Pregnancy Trimester, Second
Ultrasonography, Prenatal* / methods

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