Document Detail

Fetal lamb coagulation system during birth asphyxia.
MedLine Citation:
PMID:  3407640     Owner:  NLM     Status:  MEDLINE    
Levels of many coagulation factors are low in the healthy infant and even lower in the asphyxiated premature infant. We investigated whether a brief exposure to asphyxia at the time of birth causes the activation and consumption of coagulation factors. Following delivery by caesarean section, premature lambs were asphyxiated by occluding the endotracheal tube for 10 min and then resuscitated. Blood was obtained prior to and following birth for measurement of blood gases and the coagulation system. Birth asphyxia in the premature lamb resulted in thrombin generation and rapid consumption of specific coagulation factors.
M Andrew; H O'Brodovich; L Mitchell
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hematology     Volume:  28     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-09-14     Completed Date:  1988-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-3     Citation Subset:  IM    
Department of Pediatrics and Pathology, McMaster University Medical Centre, Hamilton, Ontario, Canada.
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MeSH Terms
Animals, Newborn / blood*
Asphyxia Neonatorum / blood*
Blood Coagulation*
Blood Coagulation Tests
Disease Models, Animal
Fetal Blood
Gestational Age
Infant, Newborn
Sheep / embryology

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