Document Detail

Fetal karyotyping in twin pregnancies: selection of technique by measurement of fetal nuchal translucency.
MedLine Citation:
PMID:  8813308     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the usefulness of selecting the appropriate technique for fetal karyotyping in twin pregnancies by using maternal age and fetal nuchal translucency thickness to determine risk for chromosomal defects in each fetus. SETTING: Fetal Medicine Centre, London, United Kingdom. SUBJECTS: Sixty-seven twin pregnancies identified at the time of an ultrasound scan for determination of fetal nuchal translucency thickness, where the parents requested karyotyping. INTERVENTION: The risk for chromosomal defects in each fetus was calculated from the maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation. If the estimated risk for either fetus was 1 in 50 or greater, chorion villus sampling was the method of choice, whereas if the risk was less than 1 in 50 second trimester amniocentesis was performed. RESULTS: The estimated risk for trisomies was more than 1 in 50 in 34 pregnancies and 23.5% of these fetuses were found to be chromosomally abnormal. In contrast, in the 33 low risk pregnancies chromosomal abnormalities were found in only 1.5% of the fetuses. CONCLUSIONS: In twin pregnancies the technique for fetal karyotyping may by selected by calculating the risk for chromosomal abnormality based on maternal age and fetal nuchal translucency thickness.
N J Sebire; P L Noble; A Psarra; G Papapanagiotou; K H Nicolaides
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  103     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  887-90     Citation Subset:  AIM; IM    
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK.
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MeSH Terms
Chromosome Aberrations / diagnosis*
Chromosome Disorders
Chromosomes, Human, Pair 21
Genetic Testing
Gestational Age
Karyotyping / methods*
Maternal Age
Neck / embryology
Pregnancy Outcome
Pregnancy Trimester, First
Pregnancy, High-Risk
Prenatal Diagnosis / methods
Ultrasonography, Prenatal
Comment In:
Br J Obstet Gynaecol. 1996 Sep;103(9):viii   [PMID:  8845344 ]

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