| Fetal karyotyping in twin pregnancies: selection of technique by measurement of fetal nuchal translucency. | |
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MedLine Citation:
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PMID: 8813308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the usefulness of selecting the appropriate technique for fetal karyotyping in twin pregnancies by using maternal age and fetal nuchal translucency thickness to determine risk for chromosomal defects in each fetus. SETTING: Fetal Medicine Centre, London, United Kingdom. SUBJECTS: Sixty-seven twin pregnancies identified at the time of an ultrasound scan for determination of fetal nuchal translucency thickness, where the parents requested karyotyping. INTERVENTION: The risk for chromosomal defects in each fetus was calculated from the maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation. If the estimated risk for either fetus was 1 in 50 or greater, chorion villus sampling was the method of choice, whereas if the risk was less than 1 in 50 second trimester amniocentesis was performed. RESULTS: The estimated risk for trisomies was more than 1 in 50 in 34 pregnancies and 23.5% of these fetuses were found to be chromosomally abnormal. In contrast, in the 33 low risk pregnancies chromosomal abnormalities were found in only 1.5% of the fetuses. CONCLUSIONS: In twin pregnancies the technique for fetal karyotyping may by selected by calculating the risk for chromosomal abnormality based on maternal age and fetal nuchal translucency thickness. |
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Authors:
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N J Sebire; P L Noble; A Psarra; G Papapanagiotou; K H Nicolaides |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of obstetrics and gynaecology Volume: 103 ISSN: 0306-5456 ISO Abbreviation: Br J Obstet Gynaecol Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1996-10-24 Completed Date: 1996-10-24 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7503752 Medline TA: Br J Obstet Gynaecol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 887-90 Citation Subset: AIM; IM |
Affiliation:
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Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Aberrations
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diagnosis* Chromosome Disorders Chromosomes, Human, Pair 21 Female Genetic Testing Gestational Age Humans Karyotyping / methods* Maternal Age Neck / embryology Pregnancy Pregnancy Outcome Pregnancy Trimester, First Pregnancy, High-Risk Prenatal Diagnosis / methods Trisomy Twins* Ultrasonography, Prenatal |
| Comments/Corrections | |
Comment In:
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Br J Obstet Gynaecol. 1996 Sep;103(9):viii
[PMID:
8845344
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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