Document Detail

Fetal karyotyping by chorionic villus sampling after the first trimester.
MedLine Citation:
PMID:  10519428     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate chorionic villus sampling (CVS) as a technique for karyotyping after the first trimester by examining the incidence of result failure, confined placental mosaicism, and false positive or negative results at different gestational ages. METHODS: During a nine year period between 1989 and 1997, all results of CVS between 8 and 37 weeks of gestation provided by the Regional Cytogenetics Centre were analysed retrospectively by examining indications for CVS, weights of tissue received, gestational age at sampling and karyotype results. RESULTS: There were 2424 chorionic villus samples analysed by the direct method and/or cell culture. In 1548 cases CVS was performed before 14 weeks (Group 1), in 685 between 15 and 20 weeks (Group 2), in 160 between 21 and 28 weeks (Group 3) and in 31 cases after 29 weeks (Group 4). Although there was a trend for an increasing rate of failed direct preparation results from Groups 1 to 4 which were 3.8%, 4.7%, 5.6% and 6.6%, respectively; these results were not significantly different. There were 19 cases of confined placental mosaicism and the incidence was significantly greater in Group 3 compared with Group 1 (P < 0.05), and in Groups 3 and 4 combined compared with Group 1. There were six false positive and one false negative result following direct analysis with no significant differences between gestationar ages. CONCLUSIONS: CVS is a useful test after the first trimester, especially when a fast result is clinically required. However, after 20 weeks, when cordocentesis is available, the higher rate of cytogenetic discordancy between the placenta and the fetus means that cordocentesis may be preferable.
S G Carroll; T Davies; P M Kyle; S Abdel-Fattah; P W Soothill
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  106     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-10-29     Completed Date:  1999-10-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1035-40     Citation Subset:  AIM; IM    
Fetal Medicine Unit, St Michael's Hospital, Bristol, UK.
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MeSH Terms
Chorionic Villi Sampling / methods*
False Positive Reactions
Fetus / abnormalities*
Gestational Age
Karyotyping / methods*
Maternal Age
Pregnancy Trimester, First

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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