| Fetal or infant death in twin pregnancy: neurodevelopmental consequence for the survivor. | |
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MedLine Citation:
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PMID: 11815541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine the neurodevelopmental morbidity in the surviving twin after fetal or infant death of the co-twin. METHODS: Twin pregnancies with an antepartum or infant death delivered between 1981 and 1992 were identified from the Northern Perinatal Mortality Survey. Information on the neurodevelopmental morbidity of infant survivors of a deceased co-twin was obtained by a questionnaire sent to the community paediatrician or general practitioner. RESULTS: A total of 111 children who survived infancy after the fetal death of the co-twin (group 1) and 142 from liveborn twin pairs in which one twin died in infancy (group 2) were traced. Responses were received from 97 (87%) and 130 (92%) respectively. In group 1, the cerebral palsy prevalence was 93 (95% confidence interval (CI) 43 to 169) per 1000 infant survivors; it was more common in like-sex pairs (8/70) with a prevalence of 114 (95% CI 51 to 213) compared with 45 (95% CI 1 to 228) per 1000 infant survivors in unlike-sex pairs (1/22). The overall prevalence of neurodevelopmental morbidity (including developmental delay) was 175 (95% CI 106 to 266) per 1000. In group 2, the cerebral palsy prevalence was 154 (95% CI 84 to 223) per 1000 infant survivors in like-sex (16/104) and 77 (95% CI 9 to 251) in unlike-sex (2/26) survivors; the overall prevalence of neurodevelopmental morbidity was 246 (95% CI 172 to 320) per 1000. CONCLUSIONS: The risk of cerebral palsy is increased in the surviving twin after a fetal or infant co-twin death compared with the general twin population. Like-sex twins are at greater risk than unlike-sex. The probable cause, in addition to the consequences of prematurity, is twin-twin transfusion problems associated with monochorionicity. |
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Authors:
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S V Glinianaia; P O D Pharoah; C Wright; J M Rankin; |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 86 ISSN: 1359-2998 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-01-29 Completed Date: 2002-02-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: England |
Other Details:
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Languages: eng Pagination: F9-15 Citation Subset: AIM; IM |
Affiliation:
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Department of Epidemiology and Public Health, School of Public Health, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK. svetlana.glinianaia@ncl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Diseases
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embryology,
epidemiology,
etiology* Cause of Death Cerebral Palsy / embryology, epidemiology, etiology Diseases in Twins / embryology, epidemiology, etiology* England / epidemiology Female Fetal Death* Fetofetal Transfusion / complications Follow-Up Studies Gestational Age Humans Infant Mortality* Infant, Newborn Male Pregnancy Prevalence Risk Factors Sex Factors |
| Comments/Corrections | |
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