Document Detail


Fetal hypoxia and programming of matrix metalloproteinases.
MedLine Citation:
PMID:  21946060     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fetal hypoxia adversely affects the brain and heart development, yet the mechanisms responsible remain elusive. Recent studies indicate an important role of the extracellular matrix in fetal development and tissue remodeling. The matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs) have been implicated in a variety of physiological and pathological processes in the cardiovascular and central nervous systems. This review summarizes current knowledge of the mechanisms by which fetal hypoxia induces the imbalance of MMPs, TIMPs and collagen expression patterns, resulting in growth restriction and aberrant tissue remodeling in the developing heart and brain. Collectively, this information could lead to the development of preventive diagnoses and therapeutic strategies in the fetal programming of cardiovascular and neurological disorders.
Authors:
Wenni Tong; Lubo Zhang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-09-18
Journal Detail:
Title:  Drug discovery today     Volume:  17     ISSN:  1878-5832     ISO Abbreviation:  Drug Discov. Today     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-06     Completed Date:  2012-05-21     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9604391     Medline TA:  Drug Discov Today     Country:  England    
Other Details:
Languages:  eng     Pagination:  124-34     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / embryology,  growth & development,  pathology
Collagen / metabolism
Fetal Heart / growth & development,  pathology
Fetal Hypoxia / complications,  physiopathology*
Humans
Matrix Metalloproteinases / metabolism*
Tissue Inhibitor of Metalloproteinases / metabolism*
Grant Support
ID/Acronym/Agency:
HD31226/HD/NICHD NIH HHS; HL82779/HL/NHLBI NIH HHS; HL83966/HL/NHLBI NIH HHS; HL89012/HL/NHLBI NIH HHS; R01 HL082779/HL/NHLBI NIH HHS; R01 HL082779-04/HL/NHLBI NIH HHS; R01 HL083966/HL/NHLBI NIH HHS; R01 HL083966-05/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Tissue Inhibitor of Metalloproteinases; 9007-34-5/Collagen; EC 3.4.24.-/Matrix Metalloproteinases
Comments/Corrections

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