Document Detail


Fetal hypothyroidism complicating medical treatment of thyrotoxicosis in pregnancy.
MedLine Citation:
PMID:  51697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two women with thyrotoxicosis were treated with antithyroid drugs during pregnancy. One women had inadvertently received a therapeutic dose of radioiodine at 21 weeks gestation and the other suffered from severe thyrotoxicosis with a serum LATS level of 1850%. In both patients, the serum triiodothyronine was maintained above 500 ng/dl by the concurrent oral administration of this hormone. Despite this precaution, cord serum thyrotrophin levels were markedly elevated and both infants showed clinical signs of hypothyroidism at birth. This experience indicates that triiodothyronine does not prevent fetal hypothyroidism when given to the mother in pharmacological amounts.
Authors:
H K Ibbertson; R J Seddon; M S Croxson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical endocrinology     Volume:  4     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1975-12-20     Completed Date:  1975-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  521-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antithyroid Agents / adverse effects*,  therapeutic use
Female
Fetal Diseases / chemically induced*
Humans
Hyperthyroidism / drug therapy*
Hypothyroidism / chemically induced*
Infant, Newborn
Pregnancy
Pregnancy Complications / drug therapy*
Chemical
Reg. No./Substance:
0/Antithyroid Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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