Document Detail

Fetal hypothyroidism complicating medical treatment of thyrotoxicosis in pregnancy.
MedLine Citation:
PMID:  51697     Owner:  NLM     Status:  MEDLINE    
Two women with thyrotoxicosis were treated with antithyroid drugs during pregnancy. One women had inadvertently received a therapeutic dose of radioiodine at 21 weeks gestation and the other suffered from severe thyrotoxicosis with a serum LATS level of 1850%. In both patients, the serum triiodothyronine was maintained above 500 ng/dl by the concurrent oral administration of this hormone. Despite this precaution, cord serum thyrotrophin levels were markedly elevated and both infants showed clinical signs of hypothyroidism at birth. This experience indicates that triiodothyronine does not prevent fetal hypothyroidism when given to the mother in pharmacological amounts.
H K Ibbertson; R J Seddon; M S Croxson
Related Documents :
8608817 - Morphological and biochemical effects of excessive amounts of biotin on embryonic devel...
3790447 - Erythropoiesis in pregnancy.
14171557 - Antibody to hereditary human gamma-globulin (gm) factor resulting from maternal-fetal i...
1251687 - Serum lipids and fatty acid composition of serum lecithin in the non-pregnant state in ...
402437 - Developmental effects of exposing drosophila embryos to ether vapour.
24520477 - Incompletely evaluated art leading to ectopic pregnancy and cerebral thrombosis.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical endocrinology     Volume:  4     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1975-12-20     Completed Date:  1975-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  521-3     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antithyroid Agents / adverse effects*,  therapeutic use
Fetal Diseases / chemically induced*
Hyperthyroidism / drug therapy*
Hypothyroidism / chemically induced*
Infant, Newborn
Pregnancy Complications / drug therapy*
Reg. No./Substance:
0/Antithyroid Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Report of the Inter-Society Commission for Heart Disease Resources. Optimal resources for cardiac su...
Next Document:  Association of fibrinogen and microfibrils with trophoblast basement membrane.