| Fetal hypothalamus-pituitary-adrenal axis on the road to parturition. | |
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MedLine Citation:
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PMID: 11153525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Activity of the fetal hypothalamus-pituitary-adrenal (HPA) axis waxes and wanes as a function of gestational age. 2. In a number of species, including sheep, at the end of gestation there is an increase in HPA activity, as characterized by an increase in fetal plasma glucocorticoids. 3. To a certain degree, the hypothalamus, pituitary and adrenal all act autonomously and, therefore, may be thought of as contributing to the initiation of the signal that results in the increase in steroidogenesis before birth. 4. Because it integrates sensory information from beyond as well as within the HPA axis and likely triggers developmental changes within the pituitary, the hypothalamus may be a 'first among equals' in being the ultimate source of triggering information for the HPA axis. |
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Authors:
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J Schwartz; I C McMillen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 28 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2001 Jan-Feb |
Date Detail:
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Created Date: 2001-01-10 Completed Date: 2001-03-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
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Languages: eng Pagination: 108-12 Citation Subset: IM |
Affiliation:
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Department of Physiology, The University of Adelaide, South Australia, Australia. jeff.schwartz@adelaide.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex
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drug effects,
secretion* Adrenocorticotropic Hormone / pharmacology, secretion Animals Corticotropin-Releasing Hormone / pharmacology Cycloheximide / pharmacology Female Fetus Hydrocortisone / blood Hypothalamo-Hypophyseal System / drug effects, secretion* Hypothalamus / drug effects, secretion* Labor, Obstetric / physiology* Pituitary Gland / drug effects, secretion* Pituitary-Adrenal System / drug effects, secretion* Pregnancy Protein Synthesis Inhibitors / pharmacology Sheep |
| Chemical | |
Reg. No./Substance:
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0/Protein Synthesis Inhibitors; 50-23-7/Hydrocortisone; 66-81-9/Cycloheximide; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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