Document Detail

Fetal hypothalamus-pituitary-adrenal axis on the road to parturition.
MedLine Citation:
PMID:  11153525     Owner:  NLM     Status:  MEDLINE    
1. Activity of the fetal hypothalamus-pituitary-adrenal (HPA) axis waxes and wanes as a function of gestational age. 2. In a number of species, including sheep, at the end of gestation there is an increase in HPA activity, as characterized by an increase in fetal plasma glucocorticoids. 3. To a certain degree, the hypothalamus, pituitary and adrenal all act autonomously and, therefore, may be thought of as contributing to the initiation of the signal that results in the increase in steroidogenesis before birth. 4. Because it integrates sensory information from beyond as well as within the HPA axis and likely triggers developmental changes within the pituitary, the hypothalamus may be a 'first among equals' in being the ultimate source of triggering information for the HPA axis.
J Schwartz; I C McMillen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  28     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    2001 Jan-Feb
Date Detail:
Created Date:  2001-01-10     Completed Date:  2001-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  108-12     Citation Subset:  IM    
Department of Physiology, The University of Adelaide, South Australia, Australia.
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MeSH Terms
Adrenal Cortex / drug effects,  secretion*
Adrenocorticotropic Hormone / pharmacology,  secretion
Corticotropin-Releasing Hormone / pharmacology
Cycloheximide / pharmacology
Hydrocortisone / blood
Hypothalamo-Hypophyseal System / drug effects,  secretion*
Hypothalamus / drug effects,  secretion*
Labor, Obstetric / physiology*
Pituitary Gland / drug effects,  secretion*
Pituitary-Adrenal System / drug effects,  secretion*
Protein Synthesis Inhibitors / pharmacology
Reg. No./Substance:
0/Protein Synthesis Inhibitors; 50-23-7/Hydrocortisone; 66-81-9/Cycloheximide; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

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