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Fetal hyperechogenic bowel may indicate congenital cytomegalovirus disease responsive to immunoglobulin therapy.
MedLine Citation:
PMID:  22506668     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To determine if fetal hyperechogenic bowel is associated with a poor outcome with or without immunoglobulin therapy. Methods: Sixteen pregnant women whose 17 fetuses had hyperechogenic bowel were followed by a protocol of offering additional serologic testing, amniocentesis, immunoglobulins, serial ultrasounds, and evaluation of their children. Results: Of 17 fetuses with hyperechogenic bowel, 13 showed hyperechogenic bowel as a single or first ultrasound sign compared to 4 who showed it concomitantly or after other ultrasound abnormalities appeared (P = 0.02). Of the 17 fetuses with hyperechogenic bowel, 9 were treated with immunoglobulins. Eight of the nine were normal at birth and during a follow up of 3 to 8 years. One treated fetus is deaf at 4 years of age. A significantly different result (P< 0.0004) occurred among 7 untreated fetuses who were each severely affected at 2 to 7 years of age, and the remaining one died soon after preterm birth. Among 7 of 9 fetuses (77.8%) of treated mothers the fetal hyperechogenic bowel resolved afterimmunoglobulins. administration. There were no significant differences between treated and untreated fetuses for gestational age at maternal infection, gestational age at birth, and birth weight. Conclusion: Hyperechogenic bowel may be a marker of congenital CMV disease, which may be prevented by immunoglobulin therapy.
Authors:
Giovanni Nigro; Stuart P Adler; Elisabetta Gatta; Giulio Mascaretti; Anastasios Megaloikonomou; Renato La Torre; Stefano Necozione
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-17
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Maternal-Infant Department, University and San Salvatore Hospital of L'Aquila, L'Aquila, Italy.
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