Document Detail

Fetal hyperechogenic bowel may indicate congenital cytomegalovirus disease responsive to immunoglobulin therapy.
MedLine Citation:
PMID:  22506668     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether fetal hyperechogenic bowel is associated with a poor outcome with or without immunoglobulin therapy.
METHODS: Sixteen pregnant women whose 17 fetuses had hyperechogenic bowel were followed by a protocol of offering additional serologic testing, amniocentesis, hyperimmunoglobulin (HIG), serial ultrasounds, and evaluation of their children.
RESULTS: Of 17 fetuses with hyperechogenic bowel, 13 showed hyperechogenic bowel as a single or first ultrasound sign compared to four who showed it concomitantly or after other ultrasound abnormalities appeared (P = 0.02). Of the 17 fetuses with hyperechogenic bowel, nine were treated with HIG. Eight of the nine were normal at birth and during a follow-up of 3-8 years. One treated fetus is deaf at 4 years of age. A significantly different result (P < 0.0004) occurred among seven untreated fetuses who were each severely affected at 2-7 years of age, and the remaining one died soon after preterm birth. Among seven of nine fetuses (77.8%) of treated mothers the fetal hyperechogenic bowel resolved after HIG administration. There were no significant differences between treated and untreated fetuses for gestational age at maternal infection, gestational age at birth, and birth weight.
CONCLUSION: Hyperechogenic bowel may be a marker of congenital cytomegalovirus (CMV) disease, which may be prevented by HIG.
Giovanni Nigro; Stuart P Adler; Elisabetta Gatta; Giulio Mascaretti; Anastasios Megaloikonomou; Renato La Torre; Stefano Necozione
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Multicenter Study     Date:  2012-05-18
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-15     Completed Date:  2013-04-30     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  2202-5     Citation Subset:  IM    
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MeSH Terms
Cytomegalovirus Infections / epidemiology,  therapy*,  ultrasonography*
Echogenic Bowel / epidemiology,  etiology*,  ultrasonography*,  virology
Follow-Up Studies
Immunization, Passive*
Infant, Newborn
Pregnancy Complications, Infectious / epidemiology,  therapy*,  ultrasonography*,  virology
Treatment Outcome
Ultrasonography, Prenatal / statistics & numerical data
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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