Document Detail

Fetal hydrocephalus and intrauterine cerebral ventriculoscopy: an animal model.
MedLine Citation:
PMID:  16113570     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to create an animal model of obstructive ventriculomegaly in the fetal lamb at 78 days of gestation by injecting maternal blood into the lateral ventricles under ultrasound guidance. METHODS: An endoscope of 1.2 mm housed in a 1.6-mm trocar was introduced into the dilated lateral ventricle. The lambs were sacrificed after delivery. RESULTS: All fetuses diagnosed with ventriculomegaly on ultrasound showed dilatation on the anatomical sections. The ventricles had a dilated aspect when compared to the controls. In 1 fetus the septum between the two ventricles was completely ruptured. Microscopically the ependymal cells were flattened and the cellular lining was disruptured. CONCLUSION: The model proved suitable for ventriculoscopic examination at 128 days of gestation. This should allow to elaborate further on therapeutic studies in this controversial area.
B De Keersmaecker; M Vloeberghs; Y Ville
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  20     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-08-22     Completed Date:  2005-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  445-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 S. Karger AG, Basel.
Department of Obstetrics and Gynaecology, Centre Hospitalier Intercommunal Poissy-Saint Germain, Poissy, France.
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MeSH Terms
Cerebral Ventricles / pathology,  ultrasonography
Disease Models, Animal*
Fetal Diseases / pathology*,  ultrasonography
Hydrocephalus / pathology*,  ultrasonography
Ultrasonography, Prenatal

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