| Fetal hemoglobin levels and morbidity in untransfused patients with β-thalassemia intermedia. | |
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MedLine Citation:
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PMID: 22096240 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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To evaluate the association between fetal hemoglobin (HbF) levels and morbidity in β-thalassemia intermedia (TI), we analyzed data from 63 untransfused patients who have also never received HbF induction therapy. Patient records were reviewed for any history of ten predefined morbidities. Laboratory measurements for markers of ineffective erythropoiesis were also obtained. The mean age of patients was 32.1 years (47.6% males) and the median HbF level was 37.2%. HbF levels correlated positively with total hemoglobin, yet negatively with growth differentiation factor-15 and non-transferrin-bound iron levels. Median HbF levels were significantly lower in patients with the majority of evaluated morbidities compared to those without. There was a strong, negative, adjusted linear correlation between the HbF level and the total number of morbidities (R(2): 0.825; p<0.001). The HbF threshold 63.7% had 95.5% sensitivity and 100% specificity for ensuring absence of morbidity. There exists a strong association between HbF levels and morbidity in the subset of untransfused patients with TI. |
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Authors:
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Khaled M Musallam; Vijay G Sankaran; Maria Domenica Cappellini; Lorena Duca; David G Nathan; Ali T Taher |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-17 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine and Medical Specialties, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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