Document Detail


Fetal hemoglobin: in vivo stimulation by D-thyroxine in adult marmosets.
MedLine Citation:
PMID:  95517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reactivation of fetal hemoglobin gene expressions was studied in new-world monkeys (marmosets). After a series of intraperitoneal injections of D-thyroxine, fetal hemoglobin production was increased in three experimental animals. Control animals were unaffected by the injection of the solvent. Because the percentage of cells containing fetal hemoglobin exceeded the total percentage of fetal hemoglobin, it was concluded that thyroid hormone influenced the synthesis of fetal hemoglobin rather than the development of a population of fetal cells.
Authors:
J E Fuhr; N Gengozian
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood cells     Volume:  5     ISSN:  0340-4684     ISO Abbreviation:  Blood Cells     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513567     Medline TA:  Blood Cells     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  471-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Callithrix / genetics*
Callitrichinae / genetics*
Dextrothyroxine / pharmacology*
Dose-Response Relationship, Drug
Fetal Hemoglobin / biosynthesis*
Gene Expression Regulation / drug effects*
Time Factors
Grant Support
ID/Acronym/Agency:
FR 5541//PHS HHS; HL 23736/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
51-49-0/Dextrothyroxine; 9034-63-3/Fetal Hemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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