| Fetal heavy chain skeletal myosin. An oncofetal antigen expressed by rhabdomyosarcoma. | |
| | |
MedLine Citation:
|
PMID: 3532837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fetal heavy chain skeletal myosin is normally present in fetal skeletal muscle. The study of 21 cases of rhabdomyosarcoma using specific antisera for fetal myosin, as well as for slow myosin, myoglobin, and desmin, led to positive findings in all cases with at least one antiserum. Desmin was localized in all cases and fetal myosin in 17 cases (81%), while myoglobin and slow myosin were present in 11 and eight cases, respectively. The localization of fetal myosin in rhabdomyosarcoma indicates that it is a type of oncofetal antigen. Because fetal myosin is found in small rhabdomyoblasts, it can be a useful marker in cases that usually constitute diagnostic problems. |
| | |
Authors:
|
V Eusebi; F Rilke; C Ceccarelli; F Fedeli; S Schiaffino; G Bussolati |
Related Documents
:
|
22741937 - Update of management of connective tissue diseases: livedoid vasculopathy. 1525097 - Clinical and histopathological features of parvovirus b19 infection in the human fetus. 9826897 - Prenatal diagnosis of an 8p23.1 deletion in a fetus with a diaphragmatic hernia and rev... 16472857 - Gain of 1q in pediatric myelodysplastic syndromes. 4095007 - Congenital spine deformities. a review of 47 cases. 23129837 - Desmoplastic medulloblastoma arising from an ovarian teratoma: a case report and review... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of surgical pathology Volume: 10 ISSN: 0147-5185 ISO Abbreviation: Am. J. Surg. Pathol. Publication Date: 1986 Oct |
Date Detail:
|
Created Date: 1986-11-20 Completed Date: 1986-11-20 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 7707904 Medline TA: Am J Surg Pathol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 680-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antigens, Neoplasm / immunology* Desmin / immunology Fetus / immunology* Humans Immune Sera / immunology Immunoenzyme Techniques Muscles / immunology* Myoglobin / immunology Myosins / immunology* Rhabdomyosarcoma / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, Neoplasm; 0/Desmin; 0/Immune Sera; 0/Myoglobin; EC 3.6.4.1/Myosins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Monoclonal antibodies to human choriocarcinoma.
Next Document: Calcitonin-secreting carcinomas of the prostate. An immunohistochemical and ultrastructural analysis...