Document Detail

Fetal heavy chain skeletal myosin. An oncofetal antigen expressed by rhabdomyosarcoma.
MedLine Citation:
PMID:  3532837     Owner:  NLM     Status:  MEDLINE    
Fetal heavy chain skeletal myosin is normally present in fetal skeletal muscle. The study of 21 cases of rhabdomyosarcoma using specific antisera for fetal myosin, as well as for slow myosin, myoglobin, and desmin, led to positive findings in all cases with at least one antiserum. Desmin was localized in all cases and fetal myosin in 17 cases (81%), while myoglobin and slow myosin were present in 11 and eight cases, respectively. The localization of fetal myosin in rhabdomyosarcoma indicates that it is a type of oncofetal antigen. Because fetal myosin is found in small rhabdomyoblasts, it can be a useful marker in cases that usually constitute diagnostic problems.
V Eusebi; F Rilke; C Ceccarelli; F Fedeli; S Schiaffino; G Bussolati
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  10     ISSN:  0147-5185     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-11-20     Completed Date:  1986-11-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  680-6     Citation Subset:  IM    
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MeSH Terms
Antigens, Neoplasm / immunology*
Desmin / immunology
Fetus / immunology*
Immune Sera / immunology
Immunoenzyme Techniques
Muscles / immunology*
Myoglobin / immunology
Myosins / immunology*
Rhabdomyosarcoma / immunology*
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Desmin; 0/Immune Sera; 0/Myoglobin; EC

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