Document Detail

Fetal haemoglobin levels in adult type 1 (insulin-dependent) diabetic patients.
MedLine Citation:
PMID:  7681416     Owner:  NLM     Status:  MEDLINE    
Glycated haemoglobin levels (HbA1 and HbA1c) are established parameters of long-term glycaemic control in diabetic patients. Depending on the method used, fetal haemoglobin interferes with the assays for glycated haemoglobin. If present in high amounts, fetal haemoglobin may lead to overestimation of glycated haemoglobin levels, and therefore, of average blood glucose concentration in diabetic patients. Glycated (HbA1c) and fetal haemoglobin levels were measured by high pressure liquid chromatography in 60 (30 female) adult Type 1 (insulin-dependent) diabetic patients of Swiss descent, and were compared with levels obtained from 60 normal, non-diabetic control subjects matched for age and sex. Fetal haemoglobin levels were significantly higher in the diabetic patients (0.6 +/- 0.1%, mean +/- SEM; range: 0-3.6%) than in the control subjects (0.4 +/- 0.1%, p < 0.001). Elevated fetal haemoglobin levels (> or = 0.6%) were found in 23 of 60 diabetic patients (38%) compared to 9 of 60 control subjects (15%; chi 2 = 8.35, p < 0.01). In addition, fetal haemoglobin levels in diabetic patients are weakly correlated with glycated haemoglobin (HbA1c) (r = 0.38, p < 0.01). Fetal haemoglobin results were confirmed with the alkali denaturation procedure, and by immunocytochemistry using a polyclonal rabbit anti-fetal haemoglobin antibody. A significant proportion of adult patients with Type 1 diabetes has elevated fetal haemoglobin levels. In certain patients this may lead to a substantial over-estimation of glycated haemoglobin levels, and consequently of estimated, average blood glucose levels. The reason for this increased prevalence of elevated fetal haemoglobin remains unclear, but it may be associated with poor glycaemic control.
P Diem; P Mullis; A Hirt; J J Schuler; W Bürgi; K A Zuppinger; A Teuscher
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Diabetologia     Volume:  36     ISSN:  0012-186X     ISO Abbreviation:  Diabetologia     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-27     Completed Date:  1993-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
Department of Medicine, University of Bern, Inselspital, Switzerland.
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MeSH Terms
Blood Glucose / analysis
Chromatography, High Pressure Liquid
Diabetes Mellitus, Type 1 / blood*
Fetal Hemoglobin / analysis*
Hemoglobin A, Glycosylated / analysis
Middle Aged
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 9034-63-3/Fetal Hemoglobin

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