| Fetal growth trajectories in Type-1 diabetic pregnancy. | |
| | |
MedLine Citation:
|
PMID: 20521236 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: To describe the individual intrauterine growth patterns of fetuses of insulin-dependent (Type-1) diabetic women and to examine determinants of overgrowth (macrosomia) and its timing. METHODS: This retrospective longitudinal study examined the developmental trajectories of fetal abdominal circumference (AC) and biparietal diameter in 76 Type-1 diabetic women with singleton pregnancies. Latent class analysis was used to identify subgroups of patients with a shared fetal AC growth trajectory. Subsequently, maternal factors, including glycemic control as assessed by glycosylated hemoglobin (HbA1c), were examined to see whether they had any effect on fetal growth. RESULTS: Four subgroups with different AC growth patterns were identified. Differences in birth weight between the distinct subgroups were related to the shape of the AC growth velocity curve over gestation. Acceleration of AC growth commencing before or after 25 weeks' gestation was associated with the birth of a heavy or large-for-dates baby in 94 and 56% of cases, respectively. Poor glycemic control (HbA1c > 7.0%) during the periconception period or before 12 weeks' gestation was a modest predictor of midtrimester growth in AC. Other diabetes-related factors, fetal sex, parity, or maternal weight/obesity were unrelated to the fetal growth pattern. CONCLUSION: The findings suggest that an individual fetus's growth trajectory is set early in gestation and that the contemporaneous degree of maternal glycemia plays a role in determining birth weight. |
| | |
Authors:
|
E J H Mulder; C M Koopman; J K Vermunt; H W de Valk; G H A Visser |
Related Documents
:
|
6158396 - Neurology and behaviour of growth-retarded neonates. relation to biochemical placental ... 18195356 - Sexual maturity in growing dinosaurs does not fit reptilian growth models. 3067166 - The diagnosis of altered fetal growth. 11489226 - Ventriculovascular physiology of the growth-restricted fetus. 10899516 - Ovarian stimulation in in vitro fertilization with or without the "long" gonadotropin-r... 11393126 - Comparative study of daily activities of pregnant and non-pregnant women after in vitro... |
Publication Detail:
|
Type: Journal Article Date: 2010-06-02 |
Journal Detail:
|
Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 36 ISSN: 1469-0705 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: England |
Other Details:
|
Languages: eng Pagination: 735-42 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
|
Department of Perinatology and Gynecology, University Medical Centre, Utrecht, The Netherlands. emulder@umcutrecht.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: High-solids biphasic CO2-H2O pretreatment of lignocellulosic biomass.
Next Document: Fetal breathing is associated with increased umbilical blood flow.