Document Detail

Fetal growth risk curves: defining levels of fetal growth restriction by neonatal death risk.
MedLine Citation:
PMID:  16769013     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We developed a fetal growth risk curve that delineates the birth weight values for gestational age that reflect a 2-, 2.5-, and 3-fold neonatal death risk relative to infants with normal fetal growth. STUDY DESIGN: We analyzed 18,085,052 single gestation infants (25-42 weeks) who were born to US resident mothers from 1996 to 2000. Multivariate models were used to predict the relationship between neonatal death and birth weight percentile. Fetal risk curves were derived on the basis of birth weight percentile-specific neonatal mortality rates that were relative to an average rate of neonatal death for a comparison group that was representative of typical growth (ie, infants between 45th-55th birth weight percentiles for gestational age). RESULTS: The 10th percentile of birth weight for gestational age is associated with an increased but variable risk of neonatal death relative to the comparison group across the spectrum of gestational ages. At 26 weeks of gestation, infants at the 10th percentile experienced a 3-fold risk of dying within the first 28 days of life (relative to the comparison group); whereas at 40 weeks, the risk was 1.13. CONCLUSION: Fetal growth risk curves facilitate the identification of populations of infants whose risk of death are deemed excessive compared with that of infants at the norm of fetal growth and may be useful for counseling pregnant women.
Sheree L Boulet; Greg R Alexander; Hamisu M Salihu; Russell S Kirby; Waldemar A Carlo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2006-06-12
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  195     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-29     Completed Date:  2006-12-21     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1571-7     Citation Subset:  AIM; IM    
Department of Maternal and Child Health, School of Public Health University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA.
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MeSH Terms
Birth Weight*
Fetal Development*
Fetal Growth Retardation / mortality*
Gestational Age*
Infant Mortality*
Infant, Newborn
Grant Support
MCJ009040//PHS HHS; T03MC00007//PHS HHS

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