| Fetal growth restriction has long-term effects on postnatal lung structure in sheep. | |
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MedLine Citation:
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PMID: 14630984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have previously shown that fetal growth restriction (FGR) during late gestation in sheep affects lung development in the near-term fetus and at 8 wk after birth. In the present study, our aim was to determine the effects of FGR on the structure of the lungs at 2 y after birth; our hypothesis was that changes observed at 8 wk after birth would persist until maturity. FGR was induced in sheep by umbilicoplacental embolization, which was maintained from 120 d until delivery at term (approximately 147 d); birth weights of FGR lambs were 41% lower than in controls. At 2 y after birth, body and lung weights were not different, but there were 28% fewer alveoli and alveoli were significantly larger than in controls; hence there was a 10% reduction in the internal surface area relative to lung volume in FGR sheep compared with controls. The lungs of FGR sheep, compared with controls, had thicker interalveolar septa as a result of increased extracellular matrix deposition; the alveolar blood-air barrier was also thicker, largely because of an 82% increase in basement membrane thickness. These changes are qualitatively similar to those observed at 8 wk. Our data show that structural alterations in the lungs induced by FGR that were apparent at 8 wk were still evident at 2 y after birth, indicating that FGR may result in permanent changes in the structure of the lungs of the offspring and may affect respiratory health and lung aging later in life. |
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Authors:
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Gert S Maritz; Megan L Cock; Samantha Louey; Keiji Suzuki; Richard Harding |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-11-19 |
Journal Detail:
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Title: Pediatric research Volume: 55 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-01-22 Completed Date: 2004-09-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 287-95 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of the West Cape, Bellville, South Africa. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals DNA / metabolism Elastin / metabolism Female Fetal Growth Retardation / pathology*, physiopathology* Lung Volume Measurements Microscopy, Electron Organ Size Oxygen / blood Pregnancy Proteins / metabolism Pulmonary Alveoli / embryology, growth & development*, pathology* Pulmonary Gas Exchange Respiratory Mucosa / metabolism, pathology, ultrastructure Sheep |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 7782-44-7/Oxygen; 9007-49-2/DNA; 9007-58-3/Elastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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