Document Detail


Fetal growth and moderate drinking in early pregnancy.
MedLine Citation:
PMID:  3946376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heavy maternal drinking during pregnancy has consistently been linked to decreased intrauterine growth, but the effect of smaller amounts of alcohol is less clear. In this study, the relationship between fetal growth and "moderate" drinking by low-risk, nonsmoking prenatal patients is explored. The sample consists of 144 women seen for the first time at the prenatal clinic of University College Obstetrics Hospital, London, England, between July 1979 and May 1980 and meeting the following criteria: white, aged 19-35 years, 8-16 weeks gestation at first prenatal visit, nonsmoker, nonalcoholic, lower middle class or higher, and in general good health. Average daily consumption of 10 g of ethanol (about one drink) in the week prior to recognition of pregnancy is related to a decrease in infant birth weight of 225 g, after adjustment for gestational age, sex of child, and maternal age, weight, height, pregnancy weight gain, social class, gravidity, and parity. In addition, consumption of this amount in the week before first prenatal visit is related to a comparable decrease in birth weight for male but not for female infants. These findings suggest that risk of decreased intrauterine growth begins very early in pregnancy, and that fetal response to later alcohol use may vary with sex of the child.
Authors:
R E Little; R L Asker; P D Sampson; J H Renwick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of epidemiology     Volume:  123     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-02-24     Completed Date:  1986-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  270-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking*
Birth Weight*
Female
Fetal Growth Retardation / chemically induced*
Gestational Age
Humans
Infant, Newborn
Male
Maternal Age
Maternal-Fetal Exchange
Parity
Pregnancy
Questionnaires
Sex Factors
Social Class

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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