| Fetal gonadal histology in XXXXY, XYY and XXX syndromes. | |
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MedLine Citation:
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PMID: 7418248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During a 3-year period in which 1500 amniotic fluid samples were studied, six cases of sex chromosome abnoramlity were detected antenatally: two with XXX, three with XYY and one with XXXXY sex chromosome constitution. After careful counselling, the parents in each case chose termination of the pregnancy, which was performed at the 20th week of gestation. All fetuses appeared normal and showed no gross malformations. Histologic investigation of the gonads of the XXXXY, one XYY and one XXX fetus showed a normal overall picture. The number of spermatogonia in the seminiferous tubules of the XXXXY male fetus was markedly reduced and the testes of the XYY fetus also contained less spermatogonia than testes from control fetuses. |
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Authors:
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H Autio-Harmainen; J Rapola; P Aula |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical genetics Volume: 18 ISSN: 0009-9163 ISO Abbreviation: Clin. Genet. Publication Date: 1980 Jul |
Date Detail:
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Created Date: 1980-12-18 Completed Date: 1980-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0253664 Medline TA: Clin Genet Country: DENMARK |
Other Details:
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Languages: eng Pagination: 1-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Induced Amniocentesis Female Fetus / pathology* Genetic Counseling Gonads / pathology* Humans Klinefelter Syndrome / pathology Male Ovary / pathology Pregnancy Sex Chromosome Aberrations / pathology* Testis / pathology X Chromosome XYY Karyotype / pathology |
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