Document Detail

Fetal gonadal histology in XXXXY, XYY and XXX syndromes.
MedLine Citation:
PMID:  7418248     Owner:  NLM     Status:  MEDLINE    
During a 3-year period in which 1500 amniotic fluid samples were studied, six cases of sex chromosome abnoramlity were detected antenatally: two with XXX, three with XYY and one with XXXXY sex chromosome constitution. After careful counselling, the parents in each case chose termination of the pregnancy, which was performed at the 20th week of gestation. All fetuses appeared normal and showed no gross malformations. Histologic investigation of the gonads of the XXXXY, one XYY and one XXX fetus showed a normal overall picture. The number of spermatogonia in the seminiferous tubules of the XXXXY male fetus was markedly reduced and the testes of the XYY fetus also contained less spermatogonia than testes from control fetuses.
H Autio-Harmainen; J Rapola; P Aula
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical genetics     Volume:  18     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-12-18     Completed Date:  1980-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
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MeSH Terms
Abortion, Induced
Fetus / pathology*
Genetic Counseling
Gonads / pathology*
Klinefelter Syndrome / pathology
Ovary / pathology
Sex Chromosome Aberrations / pathology*
Testis / pathology
X Chromosome
XYY Karyotype / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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