Document Detail

Fetal genotyping for platelets antigens: a precise tool for alloimmune thrombocytopenia: case report and literature review.
MedLine Citation:
PMID:  20217108     Owner:  NLM     Status:  In-Process    
INTRODUCTION: Maternal-fetal alloimmune thrombocytopenia complicates about 0.1% of all pregnancies and is associated with major fetal and neonatal morbidity and mortality, especially spontaneous central nervous system bleeding leading to death and neurological handicaps. Successful prevention and treatment depend on the identification of at-risk possible carriers of anti-platelet antibodies.
CASE REPORT: We report a case of a mother with a previous child that developed neonatal hemorrhage; HPA-5b anti-platelet antibodies were detected post-natally. During the next pregnancy, fetal genotyping confirmed the presence of HPA-5b antigen; she was treated with weekly intravenous human immunoglobulin and oral prednisone. Pregnancy evolved without remarkable features and a full-term baby was delivered, with normal platelet counts.
CONCLUSION: Fetal alloimmune thrombocytopenia is a potentially lethal condition, but early detection and prevention lead to successful outcome in most cases.
Marcelo Luís Nomura; Egle Couto; Beatriz Moraes Martinelli; Maria Lourdes Barjas-Castro; Ricardo Barini; Renato Passini Júnior; Vagner Castro
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Publication Detail:
Type:  Journal Article     Date:  2010-03-09
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  282     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  573-5     Citation Subset:  IM    
Hematology and Hemotherapy Center, Centro de Atenção Integral à Saúde da Mulher (CAISM), Universidade Estadual de Campinas (Unicamp), Cidade Universitária, CEP 13084-881 Campinas, SP, Brazil.
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