Document Detail

Fetal genotype for specific inherited thrombophilias is not associated with severe preeclampsia.
MedLine Citation:
PMID:  15784506     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Little is known about the association between fetal thrombophilias and severe preeclampsia. The objective of this study was to examine the association between fetal genotype for factor V Leiden, prothrombin, and methylene tetrahydrofolate reductase (MTHFR) mutations and severe preeclampsia. METHODS: Patients with severe preeclampsia or HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome admitted to Georgetown University Hospital were retrospectively identified. Controls were patients with uncomplicated, term deliveries. Fetal DNA was extracted from placental specimens and amplified by polymerase chain reaction (PCR) with locus-specific primers. The presence of polymorphisms was determined by enzymatic digestion with specific enzymes, and analyzed by polyacrylamide gels. Statistical analysis used Student t test for continuous variables and Fisher exact test for categorical data. RESULTS: Patients with preeclampsia (n = 27) and controls (n = 17) were similar for maternal age, but, as expected, they were significantly different for gestational age at delivery, birth weight, Apgar scores at 5 minutes, rate of preterm delivery less than 37 weeks, and fetal growth restriction (all P <.05). DNA extraction was successful in 25 of 27 cases from the severe preeclampsia group and 14 of 17 controls. None of the placentas analyzed in the preeclamptic or control group revealed mutations in the factor V Leiden or prothrombin genes. There was no significant difference in the rate of fetuses heterozygous for MTHFR in the preeclampsia versus control group (48% vs 43%, P >.05). CONCLUSION: In our study, fetal genotype for specific inherited thrombophilias does not appear to be associated with severe preeclampsia.
Heather Stanley-Christian; Alessandro Ghidini; Ronald Sacher; Manijeh Shemirani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Society for Gynecologic Investigation     Volume:  12     ISSN:  1071-5576     ISO Abbreviation:  J. Soc. Gynecol. Investig.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-23     Completed Date:  2005-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433806     Medline TA:  J Soc Gynecol Investig     Country:  United States    
Other Details:
Languages:  eng     Pagination:  198-201     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC, USA.
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MeSH Terms
Case-Control Studies
Factor V / genetics
Fetal Diseases / genetics*
HELLP Syndrome / genetics
Infant, Newborn
Infant, Small for Gestational Age
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Placenta / physiology
Pre-Eclampsia / genetics*
Premature Birth
Prothrombin / genetics
Thrombophilia / genetics*
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC Reductase (NADPH2)

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