| Fetal genotype for specific inherited thrombophilias is not associated with severe preeclampsia. | |
| | |
MedLine Citation:
|
PMID: 15784506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Little is known about the association between fetal thrombophilias and severe preeclampsia. The objective of this study was to examine the association between fetal genotype for factor V Leiden, prothrombin, and methylene tetrahydrofolate reductase (MTHFR) mutations and severe preeclampsia. METHODS: Patients with severe preeclampsia or HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome admitted to Georgetown University Hospital were retrospectively identified. Controls were patients with uncomplicated, term deliveries. Fetal DNA was extracted from placental specimens and amplified by polymerase chain reaction (PCR) with locus-specific primers. The presence of polymorphisms was determined by enzymatic digestion with specific enzymes, and analyzed by polyacrylamide gels. Statistical analysis used Student t test for continuous variables and Fisher exact test for categorical data. RESULTS: Patients with preeclampsia (n = 27) and controls (n = 17) were similar for maternal age, but, as expected, they were significantly different for gestational age at delivery, birth weight, Apgar scores at 5 minutes, rate of preterm delivery less than 37 weeks, and fetal growth restriction (all P <.05). DNA extraction was successful in 25 of 27 cases from the severe preeclampsia group and 14 of 17 controls. None of the placentas analyzed in the preeclamptic or control group revealed mutations in the factor V Leiden or prothrombin genes. There was no significant difference in the rate of fetuses heterozygous for MTHFR in the preeclampsia versus control group (48% vs 43%, P >.05). CONCLUSION: In our study, fetal genotype for specific inherited thrombophilias does not appear to be associated with severe preeclampsia. |
| | |
Authors:
|
Heather Stanley-Christian; Alessandro Ghidini; Ronald Sacher; Manijeh Shemirani |
Related Documents
:
|
12611826 - Do hypertension and diuretic treatment in pregnancy increase the risk of schizophrenia ... 8312216 - Spontaneous rupture of the liver in severe preeclampsia. case report. 3171856 - Uric acid levels: a useful index of the severity of preeclampsia and perinatal prognosis. 835636 - A prospective study of angiotensin ii pressor responsiveness in pregnancies complicated... 6653796 - The relationship of tubal blockage, infertility of unknown cause, suspected male infert... 1878496 - Fetal assessment in postterm pregnancy. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the Society for Gynecologic Investigation Volume: 12 ISSN: 1071-5576 ISO Abbreviation: J. Soc. Gynecol. Investig. Publication Date: 2005 Apr |
Date Detail:
|
Created Date: 2005-03-23 Completed Date: 2005-08-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9433806 Medline TA: J Soc Gynecol Investig Country: United States |
Other Details:
|
Languages: eng Pagination: 198-201 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Case-Control Studies Factor V / genetics Female Fetal Diseases / genetics* HELLP Syndrome / genetics Heterozygote Humans Infant, Newborn Infant, Small for Gestational Age Methylenetetrahydrofolate Reductase (NADPH2) / genetics Mutation Placenta / physiology Pre-Eclampsia / genetics* Pregnancy Premature Birth Prothrombin / genetics Thrombophilia / genetics* |
| Chemical | |
Reg. No./Substance:
|
0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of the anti-angiogenic factor endostatin in intrauterine growth restriction.
Next Document: The impact of interpregnancy interval and previous preterm birth on the subsequent risk of preterm b...