Document Detail

Fetal general movements and brain sonography in a population at risk for preterm birth.
MedLine Citation:
PMID:  20188499     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: General movements (GMs) assessed three months post term are related to brain injury and neurological outcome. AIMS: To study GMs in fetuses and their predictive value for echogenicity changes in the fetal brain. STUDY DESIGN: Prospective study of fetal GMs (classified as normal or abnormal) and echogenicity changes in the periventricular, basal ganglia/thalami area, and ventricular system (classified as absent, mild or moderate). SUBJECTS: 121 fetuses from pregnancies affected by hypertensive disorders and/or preterm labour, at risk for preterm birth (26-34weeks gestational age). OUTCOME MEASURES: Prevalence of abnormal GMs, GM parameters (amplitude, speed and complexity), and moderate echogenicity changes in the fetal brain (periventricular >or=IB, intraventricular grade II/III, and basal ganglia/thalamus locally increased). Predictive values of GMs for clinical parameters and moderate echogenicity changes. RESULTS: GMs were abnormal in 58%, with amplitude affected in 96%, and speed and complexity in 59%. Abnormal GMs correlated with oligohydramnios (p=0.002) and hypertensive disorders (p=0.015). Echogenicity changes of the brain were absent, mild and moderate in 27%, 39% and 31%, respectively. The sensitivity of GMs for moderate echogenicity changes in the three areas combined was 0.65, and the periventricular area 0.85, specificity both 0.44, negative predictive values 0.73 and 0.96 respectively. CONCLUSIONS: Qualitative abnormal GMs are frequent in fetuses of compromised pregnancies, and correlate with hypertensive disorders and oligohydramnios. The amplitude of GMs was most frequently affected. Abnormal GMs relate to moderate echogenicity changes especially in the periventricular area of the fetal brain, while normal GMs predict absence of moderate echogenicity changes.
F M F Rosier-van Dunn?; G van Wezel-Meijler; M P S Bakker; H J Odendaal; J I P de Vries
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Publication Detail:
Type:  Journal Article     Date:  2010-02-25
Journal Detail:
Title:  Early human development     Volume:  86     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-09     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Research Institute MOVE, VU University Medical Centre, Amsterdam, The Netherlands.
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MeSH Terms
Basal Ganglia / ultrasonography
Brain / embryology*
Cerebral Ventricles / ultrasonography
Echoencephalography / methods*
Fetal Movement / physiology*
Gestational Age
Oligohydramnios / physiopathology
Pre-Eclampsia / physiopathology
Predictive Value of Tests
Premature Birth / ultrasonography*
Prospective Studies
Psychomotor Disorders / complications,  ultrasonography*
Ultrasonography, Prenatal*

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