| Fetal fibronectin testing in patients with short cervix in the midtrimester: can it identify optimal candidates for ultrasound-indicated cerclage? | |
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MedLine Citation:
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PMID: 19070833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of the study was to determine the relationship between fetal fibronectin (fFN) testing prior to ultrasound-indicated cerclage and obstetric outcome. STUDY DESIGN: Singleton pregnancies between 18 and 24 weeks' gestation with an ultrasound-diagnosed short cervix (< 25 mm) and funneling (> 25%) of the chorioamniotic membranes into the endocervical canal were analyzed. The fFN testing was performed and patients were randomized to cerclage or no-cerclage. Groups were stratified by fFN result. Cerclage patients were compared with no-cerclage patients. The primary outcome was delivery prior to 35 weeks' gestation. RESULTS: Spontaneous preterm birth prior to 35 weeks' gestation occurred in 15 (44.1%) fFN-positive-cerclage patients and 16 (55.2%) fFN-positive no-cerclage patients (P = .45). Similarly, it occurred in 16 (17.8%) fFN-negative cerclage patients and 11 (17%) fFN-no-cerclage patients (P = .99). CONCLUSION: fFN did not identify optimal candidates for cerclage. However, fFN testing before an ultrasound-indicated cerclage aids in counseling patients, anticipating the outcome of pregnancies complicated by cervical shortening. |
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Authors:
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Sean M Keeler; Ashley S Roman; Jaclyn M Coletta; Daniel G Kiefer; Martin Feuerman; Orion A Rust |
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9641393 - Cervical varices: an unusual etiology for third-trimester bleeding. 7106313 - Early therapy for the incompetent cervix in patients with habitual abortion. 1868643 - Research involving fetal drug therapy: ethical, legal, and practical considerations. |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2008-12-13 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 200 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-02 Completed Date: 2009-02-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 158.e1-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, New York University Medical Center, New York, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cerclage, Cervical* Cervix Uteri / secretion Female Fetus Fibronectins / analysis* Humans Pregnancy Pregnancy Complications / surgery*, ultrasonography Pregnancy Outcome Pregnancy Trimester, Second Premature Birth / etiology, prevention & control* Uterine Cervical Diseases / complications, surgery*, ultrasonography Vagina / secretion |
| Chemical | |
Reg. No./Substance:
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0/Fibronectins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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