| Fetal fibronectin as a predictor of vaginal birth in nulliparas undergoing preinduction cervical ripening. | |
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MedLine Citation:
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PMID: 16260515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We sought to evaluate whether the presence of a positive fetal fibronectin (> or = 50 ng/mL) in nulliparous women undergoing preinduction cervical ripening with the intracervical Foley catheter predicted vaginal birth. METHODS: This was a prospective blinded observational trial of nulliparous women undergoing preinduction cervical ripening. We excluded women who had a contraindication to vaginal birth. Cervical and vaginal fetal fibronectin specimens were obtained before preinduction cervical ripening with an intracervical Foley catheter. The managing obstetrician was blinded to these results. RESULTS: A total of 241 women met the inclusion criteria, of which 54.4% delivered vaginally. There was no difference in the rate of vaginal delivery among women with either a positive cervical fetal fibronectin (positive fetal fibronectin 55.8% compared with negative fetal fibronectin 53.3%, P = .70) or positive vaginal fetal fibronectin (positive fetal fibronectin 57.6% compared with negative fetal fibronectin 53.3%, P = .56). Women with a positive cervical fetal fibronectin did have a shorter duration of cervical ripening (fetal fibronectin-positive 229 +/- 220 minutes compared with fetal fibronectin-negative 379 +/- 193 minutes, P < .05), duration of oxytocin (fetal fibronectin-positive 655 +/- 555 minutes compared with fetal fibronectin-negative 731.5 +/- 342 minutes, P < .025) and required lower maximal doses of oxytocin (fetal fibronectin-positive 18.4 mIU/min compared with fetal fibronectin-negative 21.8 mIU/min, P = .005). Women with a positive vaginal fetal fibronectin demonstrated only a shorter duration of cervical ripening compared with their fetal fibronectin negative counterparts (fetal fibronectin-positive 300 +/- 216 minutes compared with fetal fibronectin-negative 345 +/- 201 minutes, P < .05). CONCLUSION: Fetal fibronectin does not predict vaginal delivery in nulliparous women requiring preinduction cervical ripening. LEVEL OF EVIDENCE: II-2. |
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Authors:
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Anthony Sciscione; Matthew K Hoffman; Samantha DeLuca; Anne O'Shea; Jenny Benson; Marjorie Pollock; Babak Vakili |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 106 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-01 Completed Date: 2006-02-07 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 980-5 Citation Subset: AIM; IM |
Affiliation:
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Departments of Obstetrics and Gynecology, Drexel University College of Medicine, 245 N. 15th Street, Mail Stop 495, Philadelphia, PA 19102, USA. Anthony.Sciscione@drexelmed.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cervical Ripening / metabolism* Cervix Uteri / metabolism* Cohort Studies Female Fibronectins / metabolism* Glycoproteins / metabolism* Humans Labor, Induced* Parity / physiology Predictive Value of Tests Pregnancy Pregnancy Outcome Term Birth / metabolism Vagina / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/FFN protein, human; 0/Fibronectins; 0/Glycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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