| Fetal fibronectin as predictor of successful induction of mid-trimester abortion. | |
| | |
MedLine Citation:
|
PMID: 15762972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Fetal fibronectin (FFN) in cervical secretion is one of the most effective markers of pre-term and term delivery. The presence of FFN in cervicovaginal secretions has recently been shown to reflect cervical state and an uncomplicated induction of labor at term. This study was designed to determine whether FFN could be a biochemical marker to predict the response to prostaglandins in early mid-trimester abortion. METHODS: The presence of cervical FFN was evaluated by means of qualitative rapid immunoassay in 270 patients, who required second trimester termination of pregnancy at the Department of Gynecology and Obstetrics, University of Naples 'Federico II'. According to the standard protocol of our unit, women received 1.0 mg of gemeprost intravaginally at 3-hr intervals up to a maximum of five suppositories. The induction-to-abortion interval and the percentage of successful abortions within 24 hr in women in the positive FFN group (n=19) were compared with those in the negative FFN group (n=251). RESULTS: FFN in the cervical secretions was present in seven women (10.2%) at 16-weeks gestation, in seven women (7.5%) at 17-weeks gestation, and in five women (4.5%) at 18-week gestation. Final termination rates were 13 (68.4%) in the fibronectin-positive group and 177 (70.5%) in the fibronectin-negative group. The median abortion interval was similar (14.7 versus 15.1 hr) in both groups. CONCLUSIONS: A positive cervical fetal fibronectin test does not predict a successful medical termination of pregnancy in second trimester abortion. In this setting, the role of fetal cervical fibronectin in cervical ripening is, therefore, questionable. |
| | |
Authors:
|
Francesco Mercorio; Antonio Mercorio; Carmela Votino; Attilio Di Spiezio Sardo; Gian Vincenzo Barba; Carmine Nappi |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta obstetricia et gynecologica Scandinavica Volume: 84 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2005 Apr |
Date Detail:
|
Created Date: 2005-03-14 Completed Date: 2005-05-19 Revised Date: 2005-10-04 |
Medline Journal Info:
|
Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: Denmark |
Other Details:
|
Languages: eng Pagination: 390-4 Citation Subset: IM |
Affiliation:
|
Department of Gynecology and Obstetrics, and Pathophysiology of Human Reproduction, University of Naples Federico II, Italy. fmercorio@libero.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortifacient Agents, Nonsteroidal
/
administration & dosage Abortion, Eugenic* Adult Alprostadil / administration & dosage, analogs & derivatives* Biological Markers / analysis Cervix Mucus / chemistry* Female Fibronectins / analysis* Glycoproteins / analysis* Gravidity Humans Predictive Value of Tests Pregnancy Pregnancy Trimester, Second* Prospective Studies Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Abortifacient Agents, Nonsteroidal; 0/Biological Markers; 0/FFN protein, human; 0/Fibronectins; 0/Glycoproteins; 64318-79-2/gemeprost; 745-65-3/Alprostadil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prospective randomized comparison of single-dose versus 1-day cefazolin for prophylaxis in gynecolog...
Next Document: Changes in attitudes, knowledge and hormone replacement therapy use: a comparative study in two rand...