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Fetal fibronectin as a predictor of spontaneous preterm birth: a European perspective.
MedLine Citation:
PMID:  20670094     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Preterm birth (PTB) is estimated to account for 6-10% of all births worldwide with 13 million PTBs occurring annually and 1 million resulting in death. The diagnosis of spontaneous preterm labor and accurate prediction of preterm delivery is notoriously difficult. Identification of effective risk assessment markers can potentially improve outcomes by enabling targeted therapy while allowing efficient use of resources and avoiding unnecessary interventions. Advances in perinatal medicine have not reduced PTB and effective measures that improve outcome are yet to be established. However, considerable progress has been made in the development of accurate methods (fetal fibronectin and cervical length assessment) to predict PTB in both symptomatic and asymptomatic high-risk women. The excellent negative predictive value of fFN has the ability to facilitate decision-making regarding admission, in utero transfer, administration of antenatal corticosteroids and/or tocolysis and has been shown to be cost-effective. This review describes the European perspective on the use of fFN and describes ongoing European clinical studies, which are appropriately designed with meaningful endpoints, which will undoubtedly facilitate a better understanding of test accuracy and cost-effectiveness within different populations.
Authors:
Manju Chandiramani; Gian C Di Renzo; Elisabeth Gottschalk; Hanns Helmer; Wolfgang Henrich; Irene Hoesli; Ben Mol; Jane E Norman; Stephen Robson; Steven Thornton; Andrew Shennan
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Publication Detail:
Type:  Journal Article     Date:  2010-07-29
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  24     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  330-6     Citation Subset:  IM    
Affiliation:
Department of Women's Health, St Thomas' Hospital, King's College London, London, UK. manju.chandiramani@kcl.ac.uk
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