| Fetal exposure to isotretinoin-an international problem. | |
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MedLine Citation:
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PMID: 18077132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Isotretinoin is a known teratogen. Pregnancy prevention programs aimed at minimizing isotretinoin exposure in pregnancy have been implemented in North America with limited success. OBJECTIVE: To compare the management of fetal risk of isotretinoin in three countries, including information given to women, implementation of contraceptive methods, and pregnancy outcomes. METHODS: Pregnant women exposed to isotretinoin who called teratogen information services (TIS) in Israel, Italy and Canada between July 1998 and October 2006 were interviewed at the time of initial consultation and after the expected day of delivery. RESULTS: Fifty-three pregnant women exposed to isotretinoin contacted the TIS. Only 41% reported using a birth control method. Just one patient reported using two different forms. Forty-five percent of exposed pregnancies were terminated before delivery and 22% delivered healthy babies. Two babies were born with malformations. CONCLUSIONS: Since isotretinoin-exposed pregnancies still occur, there is a need for more effective strategies, which should take into account the cultural differences. |
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Authors:
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Facundo Garcia-Bournissen; Lilach Tsur; Lee H Goldstein; Arthur Staroselsky; Marina Avner; Farhan Asrar; Matitiahu Berkovitch; Gianluca Straface; Gideon Koren; Marco De Santis |
Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2007-10-25 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 25 ISSN: 0890-6238 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-31 Completed Date: 2008-05-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 124-8 Citation Subset: IM |
Affiliation:
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Division of Clinical Pharmacology & Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology*,
prevention & control Abortion, Therapeutic* Adult Canada Contraception* Dermatologic Agents / toxicity* Drug Information Services* Female Fetus / drug effects* Follow-Up Studies Guideline Adherence Health Knowledge, Attitudes, Practice Humans Infant, Newborn Isotretinoin / toxicity* Israel Italy Live Birth Patient Education as Topic Practice Guidelines as Topic Pregnancy Pregnancy Trimester, First Questionnaires Teratogens* World Health |
| Chemical | |
Reg. No./Substance:
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0/Dermatologic Agents; 0/Teratogens; 4759-48-2/Isotretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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